Elucidation of immune escape mechanisms by periodontopathic bacteria
Project/Area Number |
21792112
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
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Research Institution | Niigata University |
Principal Investigator |
HONDA Tomoyuki Niigata University, 医歯学系, 特任助教 (30447635)
|
Research Collaborator |
TAKAHASHI Naoki 新潟大学, 大学院・医歯学総合研究科
KAJITA Keiko 新潟大学, 医歯学総合病院, 医員
OKUI Takafumi 新潟大学, 医歯学系, 特任助教
|
Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | Porphyromonas gingivalis / LPS / microRNA / miR-146a / 歯周病原細菌 / Lipopolysaccharide / 免疫回避 |
Research Abstract |
P.gingivalis stimulation up-regulated the expression of miR-146a in macrophages. Over expression of miR-146a in macrophages attenuated the release of P.gingivalis-induced inflammatory cytokines. Further studies are required to elucidate the exact role of microRNA in periodontal pathogenesis.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] 歯周炎患者におけるPorphyromonas gingivalisに対する抗体価と高感度CRPの関連性2009
Author(s)
宮下博孝, 米澤大輔, 本田朋之, 奥井隆文, 梶田桂子, 前川知樹, 高橋直紀, 伊藤晴江, 中島貴子, 多部田康一, 山崎和久
Organizer
第52回秋季日本歯周病学会学術大会
Place of Presentation
宮崎
Year and Date
2009-10-11
Related Report
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