| Project/Area Number |
21792112
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
HONDA Tomoyuki Niigata University, 医歯学系, 特任助教 (30447635)
|
|---|
| Research Collaborator |
TAKAHASHI Naoki 新潟大学, 大学院・医歯学総合研究科
KAJITA Keiko 新潟大学, 医歯学総合病院, 医員
OKUI Takafumi 新潟大学, 医歯学系, 特任助教
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | Porphyromonas gingivalis / LPS / microRNA / miR-146a / 歯周病原細菌 / Lipopolysaccharide / 免疫回避 |
|---|
| Research Abstract |
P.gingivalis stimulation up-regulated the expression of miR-146a in macrophages. Over expression of miR-146a in macrophages attenuated the release of P.gingivalis-induced inflammatory cytokines. Further studies are required to elucidate the exact role of microRNA in periodontal pathogenesis.
|
