| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Periodontal bacteria are the causative agents in periodontitis, but subsequent progression and disease severity are thought to be determined by the host immune responses. It was reported that CD4^+CD25^+ regulate T cell existed and might have roles in progress of periodontitis. The aim of this study was to make CD4+CD25+ Tr cell's roles in periodontitis. CD4^+CD25^+ Tr suppressed proliferation of CD4^+CD25- T cells. After CD4^+CD25^+ Tr was stimulate by Dynabeads HumanT-Activator CD3/CD28, The ability of suppression was reduced. This was suggested that the ability of suppression in CD4^+CD25^+ Tr might be reduced by the stimulation.
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