| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Fibrinogen is an acute-phase protein synthesized both by hepatic and nonhepatic cells in response to proinflammatory cytokines such as IL-6. We have demonstrated that the -1420G/A, -854G/A and -148C/T polymorphisms in the β-fibrinogen promoter region are determinants of IL6-induced activity, and could be functional polymorphisms. While, it is reported that there is a strong linkage disequilibrium in some races among the 4 common polymorphisms (-1420G/A, -993C/T, -455G/A and -148C/T).
In the study, we performed the gene polymorphism analysis in the β-fibrinogen promoter region. The results indicated that the presence of the linkage disequilibrium among the 4 common polymorphisms in Japanese population.
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