Identification of responsible gene involved with aggressive periodontitis in consanguinity
| Project/Area Number |
21792122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
MIZUNO Noriyoshi Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (60325181)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 侵襲性歯周炎 / 原因遺伝子 |
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| Research Abstract |
I analysed two Japanese siblings from consanguineous marriages who had aggressive periodontitis. I performed a genome-wide scan of single nucleotide polymorphisms by using the GeneChip, and selected for the run of homozygous SNPs (RHSs) using homozygosity mapping. I extracted overlapped RHSs of two sublings as the candidate region. I listed up to 5 candidate genes which had non-synonymous mutation using next-generation sequencing technology.
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Report
(3 results)
Research Products
(4 results)
