Identification of responsible gene involved with aggressive periodontitis in consanguinity

Research Project

Project/Area Number	21792122
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Hiroshima University
Principal Investigator	MIZUNO Noriyoshi Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (60325181)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	侵襲性歯周炎 / 原因遺伝子
Research Abstract	I analysed two Japanese siblings from consanguineous marriages who had aggressive periodontitis. I performed a genome-wide scan of single nucleotide polymorphisms by using the GeneChip, and selected for the run of homozygous SNPs (RHSs) using homozygosity mapping. I extracted overlapped RHSs of two sublings as the candidate region. I listed up to 5 candidate genes which had non-synonymous mutation using next-generation sequencing technology.

Report

(3 results)