| Project/Area Number |
21792123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HOSOKAWA Yoshitaka The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (90346601)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯周炎 / Th17 / ケモカイン / 線維芽細胞 / 歯肉線維芽細胞 / Th17細胞 / CCL20 / カテキン |
|---|
| Research Abstract |
We examined the effect of IL-17A on CCL20 production from human gingival fibroblasts (HGF) in this study. Moreover, we investigated the affect of green tea catechins on CCL20 production in HGF. We found that IL-17A could induce CCL20 production in HGF, and green tea catchins inhibited CCL20 production in IL-17A-stimulated HGF. Therefore, IL-17A is involved in Th17 cells migration in periodontal diseased tissues to induce CCL20 production in HGF. Green tea catechins might decrease alveolar bone loss in periodontally diseased tissues to inhibit CCL20 production.
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