The development of regenerative periodontal therapy targetting for the new amelogenin binding prpteins
| Project/Area Number |
21792124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
FUKUDA Takao Kyushu University, 大学病院, 医員 (80507781)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アメロジェニン / 歯周組織 / 再生医学 / 歯学 |
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| Research Abstract |
Emdogain (enamel matrix derivative, EMD) is well recognized in periodontology, and it is used in periodontal surgery to stimulate regeneration of periodontal tissues. In this research, we investigated the proteins bound to amelogenin, to elucidate the molecules involved in the periodontal tissue regeneration. We identified new amelogenin binding proteins, YB-1 (human Y-box binding protein-1), and several cytoskeletal proteins. Our data suggest that these proteins are involved in regeneration of periodontal tissues by binding to amelogenin.
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Report
(3 results)
Research Products
(11 results)
