Establishment of Rat Periodontitis Model With Periodontal Pocket Formation and Elucidation of the Junctional Epithelium Destruction Mechanism

Research Project

Project/Area Number	21792125
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Nagasaki University
Principal Investigator	YOSHINAGA Yasunori Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (60452869)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	歯周ポケット形成 / LPS / 歯槽骨吸収 / 免疫感作 / 歯周炎モデル
Research Abstract	LPS was introduced daily into the palatal gingival sulcus of first molars in LPS-sensitized (sensitized group) or non-sentized rats (non-sensitized group). There was a significantly increase in apical migration of JE, pocket formation, bone resorption, the number of RANKL-bearing cells in the sensitized group than in the non-sensitized group. We could clearly demonstrate pocket formation and bone resorption in LPS-sensitized rats on day 30.

Report

(3 results)