• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The study of preterm low birth weight associated with periodontal disease.

Research Project

Project/Area Number 21792126
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionKagoshima University

Principal Investigator

HASEGAWA Kozue  Kagoshima University, 医歯学総合研究科, 助教 (00404492)

Co-Investigator(Renkei-kenkyūsha) NOGUCHI Kazuyuki  鹿児島大学, 医歯学総合研究科, 教授 (90218298)
DOUCHI Tsutomu  鹿児島大学, 医歯学総合研究科, 教授 (60150413)
NAKAMURA Toshiaki  鹿児島大学, 医歯学総合研究科, 助教 (60381183)
NAKAJIMA Yumiko  鹿児島大学, 医歯学総合研究科, 客員研究員 (40433081)
Research Collaborator HATAE Masayuki  鹿児島市立病院, 産婦人科, 部長
KAWAMATA Kazuya  愛育病院, 副院長
KAMITOMO Masato  鹿児島市立病院, 産婦人科, 医師
TATEISHI Fumi  鹿児島大学, 医歯学総合研究科, 大学院生
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords歯周病 / 早産・低体重児出産 / 歯周病原細菌 / 卵膜 / 炎症性物質 / 歯学 / 早産 / 低体重時出産 / メカニズム / Porphyromonas gingivalis / 絨毛膜由来細胞
Research Abstract

P.gingivalis DNA was detected in chorionic tissues from six out of 23 high-risk pregnant women. Stimulation of chorion-derived cells with P.gingivalis LPS significantly increased TLR-2 mRNA expression and induced IL-6 and IL-8 production in chorion-derived cells. P.gingivalis LPS-induced IL-6 and IL-8 production was reduced in TLR-2 gene-silenced chorion-derived cells.It is very likely that P.gingivalis staying in intrauterine tissues breaks the maintenance of a proper uterine-fetus relationship via TLR-2 by generating pro-inflammatory cytokines, which may cause premature labor.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (1 results)

  • [Journal Article] The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis.2011

    • Author(s)
      K.Hasegawa-Nakamura, F.Tateishi, T.Nakamura, Y.Nakajima, K.Kawamata, T.Douchi, M.Hatae, K.Noguchi1
    • Journal Title

      Journal of Periodontal Research (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 鹿児島県の妊婦における歯周組織調査2010

    • Author(s)
      長谷川梢、立石ふみ、中村利明、中島結実子、野口和行
    • Journal Title

      鹿児島県歯科医師会会報 Vol.89, No.669

      Pages: 8-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The possible mechanism of preterm-birth associated with periodontopathic Porphyromonas gingivalis

    • Author(s)
      Kozue Hasegawa-Nakamura, et al.
    • Journal Title

      Journal of Periodontal Research

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Porphyromonas gingivalisが早産へ関わるメカニズムの解析2010

    • Author(s)
      長谷川梢、立石ふみ、中村利明、中島結実子、上塘正人、川俣和弥、堂地勉、波多江正紀、野口和行
    • Organizer
      平成22年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Porphyromonas gingivalisが早産へ関わるメカニズムの解析2010

    • Author(s)
      長谷川梢, ら
    • Organizer
      平成22年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      福岡市日本
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Relationship between human gingival tissues and the renin-angiotensin system.2010

    • Author(s)
      Toshiaki Nakamura, Kozue Hasegawa, Kenji Sakoda, Takashi Matsuyama, Kazuyuki Noguchi
    • Organizer
      96th AAP annual meeting
    • Place of Presentation
      ハワイ(アメリカ合衆国)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] The mechanism by which Porphyromonas gingivalis is involved in preterm-birth.2010

    • Author(s)
      Kozue Hasegawa, Fumi Tateishi, Toshiaki Nakamura, Yumiko Nakajima, Masato Kamitomo, Kazuya Kawamata, Tsutomu Douchi, Masayuki Hatae, Kazuyuki Noguchi
    • Organizer
      96th AAP annual meeting
    • Place of Presentation
      ハワイ(アメリカ合衆国)
    • Related Report
      2010 Final Research Report
  • [Presentation] The mechanism by which Porphyromonas gingivalis is involved in preterm-birth2010

    • Author(s)
      Kozue Hasegawa, et al
    • Organizer
      96th AAP annual meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2010 Annual Research Report
  • [Book] 口腔と全身疾患-歯科医療は医学を補完する-(6-4早産低体重児出産)2010

    • Author(s)
      和泉雄一、古市保志、野口和行、長谷川梢
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi