| Project/Area Number |
21792126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
HASEGAWA Kozue Kagoshima University, 医歯学総合研究科, 助教 (00404492)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGUCHI Kazuyuki 鹿児島大学, 医歯学総合研究科, 教授 (90218298)
DOUCHI Tsutomu 鹿児島大学, 医歯学総合研究科, 教授 (60150413)
NAKAMURA Toshiaki 鹿児島大学, 医歯学総合研究科, 助教 (60381183)
NAKAJIMA Yumiko 鹿児島大学, 医歯学総合研究科, 客員研究員 (40433081)
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| Research Collaborator |
HATAE Masayuki 鹿児島市立病院, 産婦人科, 部長
KAWAMATA Kazuya 愛育病院, 副院長
KAMITOMO Masato 鹿児島市立病院, 産婦人科, 医師
TATEISHI Fumi 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯周病 / 早産・低体重児出産 / 歯周病原細菌 / 卵膜 / 炎症性物質 / 歯学 / 早産 / 低体重時出産 / メカニズム / Porphyromonas gingivalis / 絨毛膜由来細胞 |
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| Research Abstract |
P.gingivalis DNA was detected in chorionic tissues from six out of 23 high-risk pregnant women. Stimulation of chorion-derived cells with P.gingivalis LPS significantly increased TLR-2 mRNA expression and induced IL-6 and IL-8 production in chorion-derived cells. P.gingivalis LPS-induced IL-6 and IL-8 production was reduced in TLR-2 gene-silenced chorion-derived cells.It is very likely that P.gingivalis staying in intrauterine tissues breaks the maintenance of a proper uterine-fetus relationship via TLR-2 by generating pro-inflammatory cytokines, which may cause premature labor.
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