Clarification of the function of extracellular matrix protein POEM in the osteogenesis
| Project/Area Number |
21792129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Showa University |
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Principal Investigator |
MIYAZONO Agasa Showa University, 歯学部, 助教 (00514936)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周免疫機能学 / 細胞外基質タンパク質 / 骨芽細胞 / POEM / インテグリン / 接着因子 / TGF-β |
|---|
| Research Abstract |
POEM(pre-osteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine phosphatase μ domain) gene expression was suppressed by TGF-β via ERK1/2 and JNK. To investigate function of POEM in osteoblasts and bone formation, we determined start point transcription.
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Report
(3 results)
Research Products
(7 results)
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[Presentation] エナメル芽細胞の分化に伴うCaspase-14の発現をTGF-βが促進する2010
Author(s)
宮園あがさ, 須澤徹夫, 山本剛, 小野美樹, 相澤怜, 臼井通彦, 立川哲彦, 槇宏太郎, 山本松男, 上條竜太郎
Organizer
Journal of Oral Scienses,p121, 2009(第52回歯科基礎医学会)
Place of Presentation
船堀
Related Report
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