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Clarification of the function of extracellular matrix protein POEM in the osteogenesis

Research Project

Project/Area Number 21792129
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionShowa University

Principal Investigator

MIYAZONO Agasa  Showa University, 歯学部, 助教 (00514936)

Co-Investigator(Renkei-kenkyūsha) KAMIJO Ryutaro  昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi  昭和大学, 歯学部, 講師 (50407558)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯周免疫機能学 / 細胞外基質タンパク質 / 骨芽細胞 / POEM / インテグリン / 接着因子 / TGF-β
Research Abstract

POEM(pre-osteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine phosphatase μ domain) gene expression was suppressed by TGF-β via ERK1/2 and JNK. To investigate function of POEM in osteoblasts and bone formation, we determined start point transcription.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009

All Presentation (7 results)

  • [Presentation] エナメル芽細胞の分化に伴うCaspase-14の発現をTGF-βが促進する2010

    • Author(s)
      宮園あがさ
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] エナメル芽細胞の分化に伴うCaspase-14の発現をTGF-βが促進する2010

    • Author(s)
      宮園あがさ, 須澤徹夫, 山本剛, 小野美樹, 相澤怜, 臼井通彦, 立川哲彦, 槇宏太郎, 山本松男, 上條竜太郎
    • Organizer
      Journal of Oral Scienses,p121, 2009(第52回歯科基礎医学会)
    • Place of Presentation
      船堀
    • Related Report
      2010 Final Research Report
  • [Presentation] エナメル芽細胞におけるCaspase-14の役割2009

    • Author(s)
      宮園あがさ
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] エナメル芽細胞におけるCaspase-14の役割2009

    • Author(s)
      宮園あがさ, 須澤徹夫, 山本松男, 上條竜太郎
    • Organizer
      Journal of Oral Scienses,p139, 2009(第51回歯科基礎医学会)
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] リゾリン脂質・LPA(lysophosphatidic acid)の破骨細胞前駆細胞株Raw264.7に対する影響2009

    • Author(s)
      臼井通彦, 宮園あがさ, 山本松男
    • Organizer
      口腔組織培養学会誌,19:49-50
    • Related Report
      2010 Final Research Report
  • [Presentation] リゾリン脂質・Lysophosphatidic acid (LPA)の歯肉上皮細胞株Ca9-22への影響2009

    • Author(s)
      臼井通彦, 宮園あがさ, 山本松男
    • Organizer
      第130回日本歯科保存学会春季学術大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] LPA(lysophosphatidic acid)の歯肉扁平上皮癌細胞株Ca9-22に対する影響2009

    • Author(s)
      臼井通彦, 宮園あがさ, 府川有紀子, 林幸恵, 山本松男
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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