Mechanisms of T cell function disorder in periodontal diseases by butyrate and gingival fibroblast
| Project/Area Number |
21792131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
YAMADA Kiyoshi Nihon University, 歯学部, 助教 (30313076)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周免疫機能学 / 歯肉線維芽細胞 / 歯周病原性細菌 / 短鎖脂肪酸 / 酪酸 / T細胞 / 抗原提示細胞 / 細胞死 / サイトカイン産生 |
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| Research Abstract |
This study focused on the effect of gingival fibroblasts (GF) on impairment of immune responses in periodontal tissues caused by butyrate secreted from periodontopathic bacteria. It was suggested that GF which was prepared from periodontal diseases patients and sensitive to butyrate-dependent cell death failed to inhibit the butyrate-dependent cell death of T cells. On the contrary, butyrate-resistant healthy GF suppressed the cell death of T cells. Moreover, butyrate modified cytokine production from helper T cell subsets independently of GF. These results may imply additional mechanisms by which periodontopathic bacteria and butyrate impair the immune responses in periodontal tissues.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.2010
Author(s)
H.Ikeda, M.Miyatake, N.Koshikawa, K.Ochiai, K.Yamada, A.Kiss, M.J.Donlin, W.M.Panneton, J.D.Churchill, M.Green, A.M.Siddiqui, A.L.Leinweber, N.R.Crews, L.A.Ezerskiy, V.R.Rendell, M.M.Belcheva, C.J.Coscia.
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Journal Title
J Biol Chem 285
Pages: 38415-38427
Related Report
Peer Reviewed
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