The Clarification of pathologic regulation via Toll-like receptors on senescent lymphatic endothelial cells in oral cavity

• Project/Area Number: 21792138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KUROSHIMA Shinichiro Hokkaido University, 大学院・歯学研究科, 助教 (40443915)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: リンパ管内皮細胞 / ケモカイン / Toll様受容体 / 免疫老化 / リンパ内皮細胞 / 免疫 / 口腔組織 / 老化 / TLR4 / TLR2 / 白血球接着因子 / 炎症

Research Abstract

I investigated to clarify the pathologic regulation via toll-like receptors on senescent lymphatic endothelium in oral cavity. It was found that immune responses through toll-like receptors on lymphatic endothelium were downregulated in ageing.
It is possible that lymphatic endothelium may regulate immunesenescence system via toll-like receptors.

Research Products

• [Journal Article] A Case of Prosthodontic Rehabilitation after Maxillo-mandibular Reconstruction Using Milling and Riegel Telescopic Method. (2010)
  • Author(s): Kuroshima S.
  • Journal Title: Ann.Jpn.Prosthodont.Soc. 2(4) Pages: 287-290
  • NAID: 10029765563
  • Peer Reviewed
• [Journal Article] Generalized exacerbation of systemic allergic dermatitis due to zinc patch test and dental treatments. (2010)
  • Author(s): Saito N, Yamane N, Matsumura W, Fujita Y, Inokuma D, Kuroshima S, Hamasaka K, Shimizu H.
  • Journal Title: Contact Dermatitis. 62(6) Pages: 372-373
  • Peer Reviewed
• [Journal Article] A Case of Prosthodontic Rehabilitation after Maxillo-mandibular Reconstruction Using Milling and Riegel Telescopic Method (2010)
  • Author(s): Kuroshima S
  • Journal Title: Ann.Jpn.Prosthodont.Soc. Volume: 2 Pages: 287-290
  • NAID: 10029765563
  • Peer Reviewed
• [Journal Article] Generalized exacerbation of systemic allergic dermatitis due to zinc patch test and dental treatments. (2010)
  • Author(s): Saito N
  • Journal Title: Contact Dermatitis. Volume: 62 Pages: 372-373
  • Peer Reviewed
• [Presentation] (2011)
  • Author(s): Kuroshima S, L.McCAULEY, J.YAMASHITA
  • Organizer: 89th General Session & Exhibition of the IADR
  • Place of Presentation: カリフォルニア, アメリカ合衆国Selected Oral Presentation. Abstract No. 0423
  • Year and Date: 2011-03-17
• [Presentation] Bone Marrow Hematopoietic Cells Inhibit Osteoblast Mineralization In Vitro (2011)
  • Author(s): Kuroshima S
  • Organizer: International Association for Dental Research
  • Place of Presentation: Sandiego, CA, USA
  • Year and Date: 2011-03-17
• [Presentation] A case of prosthodontic rehabilitation after maxillo-mandibular reconstruction using Riegel telescopic method and milling technique. (2009)
  • Author(s): Kuroshima S.
  • Organizer: J.Jpn.Prosthodont.Soc.29
  • Place of Presentation: 岩手歯科医師会館8020プラザ(岩手)
  • Year and Date: 2009-10-24
• [Book] 第4回ITIコンセンサス会議議事録 (2010)
  • Author(s): (著)Stephen T.Chen、(訳)黒嶋伸一郎, ほか5名
  • Publisher: クインテッセンス出版
• [Book] 第4回 ITIコンセンサス会議議事録 (2010)
  • Author(s): Stephen T.Chen
  • Publisher: クインテッセンス出版