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Study of IGF-I effect on anti-aging for the jawbone

Research Project

Project/Area Number 21792140
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

KOJIMA Ikuho  東北大学, 大学院・歯学研究科, 助教 (80447169)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsIGF-I / 骨 / アンチエイジング / IGF-1
Research Abstract

The results of IGF-I administration for normal rat were as follows. 1)Bone mineral density (BMD)analyzed by X-ray photograph increased in lower area of mandibular condyle. 2)On measurement about bone matrix ratio (BMR), BMR was greater in lower part of mandibular condyle (Cd)vertically divided into three parts, and was greater in central part of laterally divided Cd. 3)On measurement about osteoblast, the number of osteoblasts was greater in central and lower parts of vertically divided Cd, and in inside and outside parts of laterally divided Cd. 4)On measurement about osteoclast, the number of osteoclasts has no change in any parts of Cd. 5)These changes during IGF-I administration disappeared after IGF-I administration ended.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Morphological and histopathological changes in orofacial structures of experimentally developed acromegaly-like Rats : An Overview2012

    • Author(s)
      Iikubo M, Kojima I, Sakamoto M, Kobayashi A, Ikeda H, Sasano T
    • Journal Title

      Int J Endocrinol

      Volume: 2012 Pages: 254367-254367

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and histopathological changes on orofacial sturucture of experimentally developed acromegaly-like rats: An Overview2012

    • Author(s)
      Iikubo M, Kojima I, Sakamoto M, Kobayashi A, Ikeda H, Sasano T.
    • Journal Title

      Int J Endocrinol

      Volume: 2012 Pages: 254367-254367

    • DOI

      10.1155/2012/254367

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mechanisms of edematous changes in masseter muscle evoked by muscle pain2011

    • Author(s)
      Iikubo M, Yamamura MJ, Li L, Sasaki M, Kojima I, Satoh-Kuriwada S, Shoji N, Sakamoto M, Kodama T, Sasano T
    • Organizer
      The 18th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Hiroshima
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanisms of edematous changes in masseter muscle evoked by muscle pain2011

    • Author(s)
      Iikubo M, Yamamura MJ, Li L, Sasaki M, Kojima I, et.al.
    • Organizer
      The 18th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Morphological study on the dental arch in experimentally developed acromegaly-like rats2010

    • Author(s)
      Kojima I, et.al.
    • Organizer
      8th Asian congress of Oral and Maxillofacial Radiology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Morphological study on the dental arch in experimentally developed acromegaly-like rats2010

    • Author(s)
      Kojima I, Iikubo M, Sakamoto M, Sasano T
    • Organizer
      8th Asian congress of Oral and Maxillofacial Radiology
    • Place of Presentation
      Seoul
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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