Association between periodontal disease and polymorphism related type 2 diabetes mellitus

• Project/Area Number: 21792147
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Niigata University
• Principal Investigator: MATSUMOTO Sayaka Niigata University, 医歯学総合病院, 医員 (50515749)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 予防歯科 / 臨床疫学 / 遺伝子多型 / 歯周炎 / 2型糖尿病 / 2型糖尿病感受性遺伝子

Research Abstract

The aim of this study was to investigate association between genetic factor (adiponectin gene at SNP276 and94) and periodontal disease in type 2 diabetes mellitus patients. Serum adiponectin concentration in subjects with GG type at SNP276 or TT type at SNP94 had lower than those without these SNPs (p=0.034). The subjects with these SNPs were also higher levels in periodontal status parameters, however there were not significant differences. Our results suggested that adiponectin gene at SNP94 and 276 might be associated with periodontal status.

Research Products

• [Presentation] Effect of periodontal treatment on serum leptin in diabetics. (2010)
  • Author(s): Matsumoto S.
  • Organizer: 88th General Session of IADR. 162
• [Presentation] Effect of periodontal treatment on MCP-1 in type 2 diabetics. (2010)
  • Author(s): Ogawa H, Matsumoto , et al.
  • Organizer: 88th General Session of IADR. 162
• [Presentation] Effect of periodontal treatment on serum leptin in diabetics. (2010)
  • Author(s): Matsumoto S, et al.
  • Organizer: The 88th General Session of IADR.
  • Place of Presentation: バルセロナ(スペイン)
• [Presentation] Effect of periodontal treatment on MCP-1 in type 2 diabetics. (2010)
  • Author(s): Ogawa H, et al.
  • Organizer: The 88th General Session of IADR.
  • Place of Presentation: バルセロナ(スペイン)
• [Presentation] Long-term effect of periodontal maintenance on adiponectin increase in diabetics. (2009)
  • Author(s): Matsumoto S.
  • Organizer: The 9th World Congress on Preventive Dentistry
• [Presentation] Long-term effect of periodontal maintenance on adiponectin increase in diabetics (2009)
  • Author(s): Matsumoto S, et al.
  • Organizer: The 9^<th> World congress of Preventive Dentistry Meeting
  • Place of Presentation: ヒルトンプーケットアルカディアアンドスパ(タイ)
• [Presentation] 歯周メインテナンスによる血清アディポネクチン濃度維持効果の検討 (2009)
  • Author(s): 小川祐司, 他
  • Organizer: 第58回日本口腔衛生学会・総会
  • Place of Presentation: 長良川国際会議場(岐阜県)
• [Remarks] ホームページ等