Effects of vitamin C on experimental atherosclerosis induced by periodontitis

• Project/Area Number: 21792148
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: EKUNI Daisuke Okayama University, 大学院・医歯薬学総合研究科, 助教 (70346443)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周病 / 動脈硬化 / ビタミンC / 酸化ストレス / ラットモデル

Research Abstract

In the periodontitis group, there was lipid deposition in the descending aorta and significant increases of oxidative damages compared to the control group. Vitamin C intake significantly decreased oxidative damages and changed oxidative stress-and atherosclerosis-related gene expressions.

Research Products

• [Journal Article] Effects of periodontitis on aortic insulin resistance in an obese rat model. (2010)
  • Author(s): Ekuni D, Tomofuji T, Irie K, Kasuyama K, Umakoshi M, Azuma T, Tamaki N, Sanbe T, Endo Y, Yamamoto T, Nishida T, Morita M.
  • Journal Title: Lab Invest 90 Pages: 348-359
  • Peer Reviewed
• [Journal Article] Effects of periodontitis on aortic insulin resistance in an obese rat model. (2010)
  • Author(s): Ekuni D.
  • Journal Title: Lab Invest Volume: 90 Pages: 348-59
  • Peer Reviewed
• [Journal Article] Effects of periodontitis on aortic insulin resistance in an obese rat model. (2010)
  • Author(s): Ekuni D
  • Journal Title: Lab Invest. 90 Pages: 348-359
  • Peer Reviewed
• [Journal Article] Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress. (2009)
  • Author(s): Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T.
  • Journal Title: Arch Oral Biol 54 Pages: 495-502
  • Peer Reviewed
• [Journal Article] Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress. (2009)
  • Author(s): Ekuni D
  • Journal Title: Arch Oral Biol. 54 Pages: 495-502
  • Peer Reviewed
• [Presentation] 肥満モデルラットにおける動脈のインスリン抵抗性に対する歯周炎の影響 (2009)
  • Author(s): 江國大輔
  • Organizer: 口腔衛生学会総会
  • Place of Presentation: 岐阜
• [Remarks] ホームページ等
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html
• [Remarks]
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html
• [Remarks]
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html