Effects of Hydrogen Sulphide on Osteoclast Differentiation in Rats
Project/Area Number |
21792149
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Social dentistry
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Research Institution | Okayama University |
Principal Investigator |
IRIE Kouichiro Okayama University, 岡山大学病院, 医員 (50509594)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 口臭 / 揮発性化合物 / ラット / 口臭起因物質 / LPS / 歯周組織 |
Research Abstract |
Oral malodor is mainly attributed to volatile sulphur compounds (VSCs) such as hydrogen sulphide (H_2S). VSC accelerate periodontal soft tissue destruction. However, there is little information about the potential role of H_2S in alveolar bone loss. The purpose of this animal study was to examine the effects ofH2S on osteoclast differentiation in rat periodontal tissue.H2S application caused a transient increase of osteoclast differentiation with up-regulation of RANKL expression in osteoblasts. H_2S, which is primarily responsible for halitosis, may also contribute to alveolar bone resorption through RANKL expression. H_2S and LPS had the additive effects on osteoclast differentiation through activation of TLR4 pathway.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] Cocoa-enriched diet decreases2009
Author(s)
Irie K, Tomofuji T, Ekuni D, Azuma T, Tamaki N, Endo Y, Sanbe T, Yamamoto TMorita M
Organizer
gingival oxidative stress in rat periodontitis: SFRR
Place of Presentation
Roma, Italy
Related Report
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