Effect of obesity prevention by exercise training on periodontal tissue

• Project/Area Number: 21792150
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: AZUMA Tetsuji Okayama University, 大学院・医歯薬学総合研究科, 助教 (80432649)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肥満 / 運動 / 歯周組織 / 酸化ストレス / ラット / 歯周病

Research Abstract

Studies indicate a positive correlation between obesity and periodontitis. The suppression of obesity by exercise training may offer the clinical benefits on periodontal tissue. The purpose of the present study was to investigate the effects of exercise training on periodontal tissue in obese rats fed a high-fat diet. Forty-two male Wistar rats (8 week olds) were divided into three groups : a control group (fed a regular diet) and two experimental groups (fed a high-fat diet with and without exercise training [treadmill : 5 days/ week]). The experiment period was 4 or 8 weeks. The obese rats without exercise training showed higher serum ROM levels, 8-OHdG levels in gingival tissues, and polymorphonuclear leucocytes density in the connective tissues than the control group at 8 weeks. The obese rats with exercise training showed lower serum ROM levels, gingival 8-OHdG levels, and polymorphonuclear leucocytes density than those without exercise training at 8 weeks. These results indicate that obesity prevention by exercise training could effectively suppress gingival oxidative stress and periodontal inflammation by decreasing serum ROM in rats.

Research Products

• [Journal Article] Effects of exercise training on gingival oxidative stress in obese rats. (2011)
  • Author(s): Azuma T, Tomofuji T, Endo Y, Tamaki N, Ekuni D, Irie K, Kasuyama K, Kato T, Morita M
  • Journal Title: Arch Oral Biol in press
  • NAID: 120003324226
  • Peer Reviewed
• [Journal Article] Effects of exercise training on gingival oxidative stress in obese rats (2011)
  • Author(s): Azuma T
  • Journal Title: Arch Oral Biol Volume: (in press)
  • NAID: 120003324226
  • Peer Reviewed
• [Journal Article] Imbalance of oxidative/anti-oxidative status induced by periodontitis is involved in apoptosis of rat submandibular glands. (2010)
  • Author(s): Ekuni D, Endo Y, Irie K, Azuma T, Tamaki N, Tomofuji T, Morita M
  • Journal Title: Arch Oral Biol 55 Pages: 170-176
  • Peer Reviewed
• [Journal Article] Effects of periodontitis on aortic insulin resistance in an obese rat model. (2010)
  • Author(s): Ekuni D, Tomofuji T, Irie K, Kasuyama K, Umakoshi M, Azuma T, Tamaki N, Sanbe T, Endo Y, Yamamoto T, Nishida T, Morita M
  • Journal Title: Lab Invest 90 Pages: 348-359
  • Peer Reviewed
• [Journal Article] Experimental periodontitis induces gene expression of pro-inflammatory cytokines in liver and white adipose tissues in obesity. (2010)
  • Author(s): Endo Y, Tomofuji T, Ekuni D, Irie K, Azuma T, Tamaki N, Yamamoto T, Morita M
  • Journal Title: J Periodontol 81 Pages: 520-526
  • Peer Reviewed
• [Journal Article] Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity (2010)
  • Author(s): Endo Y, Tomofuji T, Azuma T, et al.
  • Journal Title: J Periodont 81 Pages: 520526-520526
  • Peer Reviewed
• [Presentation] 運動による肥満予防がラット歯周組織に及ぼす影響 (2010)
  • Author(s): 東哲司, 入江浩一郎, 遠藤康正, 粕山健太, 加藤 朋, 江國大輔, 玉木直文, 友藤孝明, 森田学
  • Organizer: 第59回日本口腔衛生学会・総会
  • Place of Presentation: 新潟
• [Presentation] Occlusal disharmony affects BDNF levels in rat submandibular gland. (2010)
  • Author(s): Irie K, Ekuni D, Tomofuji T, Endo Y, Azuma T, Morita M.
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] 運動による肥満の予防が歯肉の酸化ストレスに及ぼす影響 (2010)
  • Author(s): 江國大輔, 東哲司, 入江浩一郎, 遠藤康正, 加藤朋, 玉木直文, 友藤孝明, 森田学
  • Organizer: 第63回日本酸化ストレス学会・学術集会
  • Place of Presentation: 神奈川