| Project/Area Number |
21792153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUKUI Makoto The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (50325289)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 口臭 / Fusobacterium nucleatum / 歯周病原細菌 / 揮発性硫黄化合物 / 揮発性硫化物 / 共凝集 |
|---|
| Research Abstract |
The aim of this study was to clarify the influence of coaggregation between Fusobacterium nucleatum, a periodont pathogenic bacteria, and other microorganisms for production of volatile sulfur compound (VSC) by F. nucleatum. The coaggregation reaction was observed between F. nucleatum and Porphyromonas gingivalis, and shown that the production of VSC was significantly enhanced by incubation with live P. gingivalis compared to incubation F. nucleatum solely. It was also observed that the gene expression of F. nucleatum enzyme related with VSC production was tended to be enhanced by incubation with live P.gingivalis together whereas no effect was shown when incubated with heat-killed microorganism or supernatant of medium of P.gingivalis.
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