Promotion of the salivary glands branching for treatment of dry mouth

• Project/Area Number: 21792154
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: FUKUMOTO Emiko Tohoku University, 病院, 助教 (10264251)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 予防歯科学 / 唾液腺 / 発生 / 口腔乾燥症 / 腺分岐

Research Abstract

GAP junction Inhibitor related to calcium and IP3 transport inhibit the PDGF-mediated salivary glands branching. PDGF induced FGF7 and FGF10 expression in mesenchymal tissue of salivary glands. We analyzed about the MAPK pathway. PDGF induced phosphorylation of ERK1/2 in developing salivary glands. It indicates that activation of MAPK pathway on epithelial cells involves the branching of salivary glands. In Cx43 knockout mice, branching of salivary gland was inhibited compared with control mice, indicating that Cx43 may be important for salivary gland morphogenesis.

Research Products

• [Journal Article] Expression and functions of neurotrophic factors in tooth development. (2011)
  • Author(s): Iwamoto T, Yamada A, Arakaki M, Sugawara Y, Ono M, Futaki M, Yoshizaki K, Fukumoto E, Nakamura T, Fukumoto S.
  • Journal Title: J Oral Biosci. 53(1) Pages: 13-21
  • NAID: 10027793552
  • Peer Reviewed
• [Journal Article] Expression and functions of neurotrophic factors in tooth development (2011)
  • Author(s): Iwamoto T, Yamada A, Fukumoto E, Fukumoto S., et al.
  • Journal Title: Journal of Oral Biosciences Volume: 53(1) Pages: 13-21
  • NAID: 10027793552
  • Peer Reviewed
• [Journal Article] Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts. (2009)
  • Author(s): Iwamoto T, Yamada A, Yuasa K, Fukumoto E, Nakamura T, Fujiwara T, Fukumoto S.
  • Journal Title: 54(10) Pages: 963-969
  • Peer Reviewed
• [Journal Article] Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation. (2009)
  • Author(s): Sonoda A, Iwamoto T, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S
  • Journal Title: 284(40) Pages: 176-184
  • Peer Reviewed
• [Journal Article] Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts (2009)
  • Author(s): Iwamoto T, Yamada A, Yuasa K, Fukumoto E, Nakamura T, Fujiwara T, Fukumoto S.
  • Journal Title: Arch Oral Biol. 54(10) Pages: 963-969
  • Peer Reviewed
• [Journal Article] Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation (2009)
  • Author(s): Sonoda A, Iwamoto T, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S.
  • Journal Title: J Biol Chem. 284(40) Pages: 176-184
  • Peer Reviewed