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Analysis of the expanding caries area mechanism by cigarette smoke exposure

Research Project

Project/Area Number 21792161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

FUJINAMI Yoshiaki  Matsumoto Dental University, 歯学部付属病院, 助手 (80392801)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords環境タバコ煙 / 受動喫煙 / 唾液 / 小児 / 齲蝕 / Cotinine / 唾液腺 / Streptococcus mutans
Research Abstract

The exposure of cigarette smoke did not change amount of saliva, activity and growth of Streptococcus mutans and component of re-calcification part. The exposure of cigarette smoke temporarily decreased the Amylase and Peroxidase activity in saliva. In the cigarette smoke-exposed rats, vasodilation and hyperemia in the parotid grand and submandibular gland were observed by histological analysis. Inflammatory cells were not found infiltrating the salivary glands. The area of caries in the cigarette smoke exposure caries rats were significantly increasing compared with the caries rats.
These results suggest that cigarette smoke exposure changes salivary component and expands caries area in the maxillary molars of rat.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] The effects of cigarette exposure on rat salivary proteins and salivary glands.2009

    • Author(s)
      Yoshiaki Fujinami, Tatsuya Fukui, Keisuke Nakano, 他7名
    • Journal Title

      Oral diseases 15

      Pages: 466-471

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of cigarette exposure on rat salivary proteins and salivary glands2009

    • Author(s)
      Yoshiaki Fujinami, et al
    • Journal Title

      Oral diseases 15

      Pages: 466-471

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] タバコ煙による齲蝕進行の可能性,タバコ煙による齲蝕進行の可能性2010

    • Author(s)
      藤波義明
    • Organizer
      第5回日本禁煙科学会学術総会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-21
    • Related Report
      2010 Final Research Report
  • [Presentation] タバコ煙による齲蝕進行の可能性2010

    • Author(s)
      藤波義明, ら
    • Organizer
      第5回 日本禁煙科学会 学術総会
    • Place of Presentation
      ホテルクレメント徳島(徳島県)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of cigarette smoke exposure on dental caries in animal model.2010

    • Author(s)
      Yoshiaki Fujinami
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] The cigarette smoke exposure influences the rat saliva and salivary glands2010

    • Author(s)
      藤波義明, et al
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Changes of Salivary Glands and Components due to Cigarette Smoke.2010

    • Author(s)
      Yoshiaki Fujinami
    • Organizer
      10th Biennial Congress of the European Association of Oral Medicine
    • Place of Presentation
      London (United Kingdom)
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes of Salivary Glands and Components due to Cigarette Smoke2010

    • Author(s)
      Yoshiaki Fujinami, et al
    • Organizer
      10th biennial conference of EAOM incorporating the World Workshop on oral medicine
    • Place of Presentation
      Central Hall Westminster (London, UK)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 齲蝕モデル動物へのタバコ煙曝露の影響2009

    • Author(s)
      藤波義明
    • Organizer
      第4回日本禁煙科学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 齲蝕モデル動物へのタバコ煙曝露の影響2009

    • Author(s)
      藤波義明, ら
    • Organizer
      第4回 日本禁煙科学会 学術総会
    • Place of Presentation
      金沢エクセルホテル東急(石川県)
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] タバコ煙曝露が及ぼすラット唾液・唾液腺への影響2009

    • Author(s)
      福井達也
    • Organizer
      第68回松本歯科大学学会(総会)
    • Place of Presentation
      長野
    • Year and Date
      2009-07-11
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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