Early detection of the atherosclerotic disease and assessment of the valvular heart disease complicated with periodontitis
| Project/Area Number |
21792164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
ARISHIRO Kumiko Osaka Dental University, 歯学部, 助教 (20460769)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周炎 / 動脈硬化 / 心臓弁膜症 / 歯周病 / アディポネクチン / バイオマーカー |
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| Research Abstract |
Recently, periodontitis has been reported to relate closely to systemic diseases including diabetes mellitus and atherosclerotic disease, but a biomaker for periodontitis status has not been established. In this project, we investigated the relevance of periodontal condition and markers for common systemic diseases. We also measured the high molecular weight (HMW) form of adiponectin, which is regarded as an active form of this cytokine. The ratio of HMW adiponectin to total adiponectin was significantly lower in subjects with periodontal pockets. Moreover, we investigated whether the Japanese basal therapy for periodontitis would improve the vascular function. The flow-mediated dilatation(FMD) improved just after the therapy and the adhesion molecules might be contributed. The results are considered to be useful for early detection and therapy of periodontitis.
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Report
(3 results)
Research Products
(18 results)
