Fundamental study on mechanism of pressure ulcer developing.-Response to pressure of skin and muscle cells.-

Research Project

Project/Area Number	21792175
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Fundamental nursing
Research Institution	Teikyo University (2010) Shiga University of Medical Science (2009)
Principal Investigator	TAKADA Naoko Teikyo University, 医療技術学部, 講師 (10432303)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	褥瘡 / 皮膚線維芽細胞 / 筋管細胞 / 機械的刺激 / アポトーシス / 低酸素刺激 / 皮膚繊維芽細胞 / 細胞外マトリックス / BMPファミリー / 発生要因
Research Abstract	The purpose of this study was reveal mechanism of pressure ulcer developing by using the cell that composed the skin and the muscle. As a result, the application of external pressure induced the expression of gene not thought to be related to the generation of the pressure ulcer before. And, the gene that increases by a current research was confirmed by the immunostaining. In addition, I made three-dimensionnal culture model that similar living body.