| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We investigated intestinal colonization by C. difficile in children undergoing antineoplastic chemotherapy. The environmental surfaces of the pediatric ward where they were hospitalized were sampled and examined for the presence of C. difficile.
C. difficile was recovered from 13 of the 15 children examined, and 2 of them were given the diagnosis of C. difficile infection and treated by vancomycin. C. difficile isolates were analyzed by PCR ribotyping. Ten patients had four PCR ribotype, which indicates nosocomial spreading in the ward. A total of 502 environmental surfaces were examined and 39 were positive for C. difficile. The 39 C. difficile isolates were classified into 18 different PCR ribotypes. The same PCR ribotype was recovered from stool specimens of 2 patients as well as from environmental surfaces of their room. These findings indicate that environmental contamination may contribute to C. difficile transmission among pediatric cancer patients.
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