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Constructive research for understanding the effects of amyloid β to neuronal function.

Research Project

Project/Area Number 21800016
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo University of Technology (2010)
Tokyo Medical and Dental University (2009)

Principal Investigator

SUZUKI Ikuro  Tokyo University of Technology, 応用生物学部, 助教 (90516311)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords神経細胞 / アミロイドβ / 多電極アレイ / 時系列解析 / チモキノン / 長期計測 / DFA / アルツハイマー病 / 脳・神経 / 自発活動 / 海馬神経細胞 / 生物物理
Research Abstract

Alzheimer's disease (AD) is characterized by the aggregation of amyloid β peptide (Aβ). The aim of this study is to investigate the effect of Amyloid Beta toxicity in embryonic rat hippocampus through chronic monitoring of neuronal cell electrical activity using multielectrode array (MEA) recordings, and the molecules protecting neurons from Aβ toxicity. Applying Aβ to cultured embryonic rat hippocampal neurons has an inhibitory effect on spontaneous activity started 24h after applying and the firing disappeared at 72h. When thymoquinone (TQ) active constituent of Nigella Sativa Oil and Aβ were simultaneously applied, thymoquinone reduces the deleterious effect of Aβ at 34h after applying. This results indicated that TQ have the potential protecting hippocampus cells from Aβ toxicity.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] 1神経細胞の長期活動ダイナミクス2009

    • Author(s)
      鈴木郁郎
    • Journal Title

      生物物理 286(49-6)

      Pages: 304-305

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1神経細胞の長期活動ダイナミクス2009

    • Author(s)
      鈴木郁郎
    • Journal Title

      生物物理 49(6)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] アミロイドβペプチドが及ぼすラット海馬神経細胞の発火頻度とチモキノンによる保護作用の検討2011

    • Author(s)
      Alhebshi Amani Hassn、鈴木郁郎、後藤正男
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] ルテニウム錯体の細胞への取り込みと局在2011

    • Author(s)
      坂本美緒、鈴木郁郎、後藤正男
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] アミロイドβペプチドが及ぼすラット海馬神経細胞の発火頻度とチモキノンによる保護作用の検討2011

    • Author(s)
      Alhebshi Amani Hassn, 鈴木郁郎, 後藤正男
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(神奈川)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ルテニウム錯体の細胞への取り込みと局在2011

    • Author(s)
      坂本美緒, 鈴木郁郎, 後藤正男
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(神奈川)
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 構成的アプローチによる細胞ネットワークの制御と動態計測2011

    • Author(s)
      鈴木郁郎
    • Organizer
      細胞制御工学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 構成的アプローチによる細胞ネットワークの制御と動態計測2011

    • Author(s)
      鈴木郁郎
    • Organizer
      細胞制御工学研究会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 単一細胞における長期自発活動のDFA解析2010

    • Author(s)
      鈴木郁郎
    • Organizer
      第33回日本神経科学会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 単一細胞における長期自発活動のDFA解析2010

    • Author(s)
      鈴木郁郎
    • Organizer
      第33回日本神経科学会、第53回日本神経化学会大会、第20回日本神経回路学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 1細胞からの構成的神経回路における長期活動ダイナミクス2009

    • Author(s)
      鈴木郁郎
    • Organizer
      「細胞を創る」研究会
    • Place of Presentation
      東京大学 鉄門講堂
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1細胞からの構成的神経回路における長期活動ダイナミクス2009

    • Author(s)
      鈴木郁郎
    • Organizer
      「細胞を創る」研究会2.0
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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