The development of An automatically-deploying subdural electrode array which can be implanted by a minimally-invasive surgery and its ASIC

• Project/Area Number: 21800023
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Shizuoka University
• Principal Investigator: YAMAKAWA Toshitaka Shizuoka University, 工学部, 助教 (60510419)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,665,000 (Direct Cost: ¥2,050,000、Indirect Cost: ¥615,000); Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000); Fiscal Year 2009: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
• Keywords: 電子デバイス・機器 / 医療・福祉 / てんかん / 脳・神経 / CMOS集積回路 / 皮質脳波センサ

Research Abstract

A novel subdural electrode array guided by a shape-memory-alloy thin wire have been developed for minimally-invasive ECoG measurement. The measured electric characteristics provided the evidences that the electrodes are suitable for ECoG measurement. The utility for ECoG measurement and the invasiveness of procedure were verified with the animal tests. An ASIC for amplification of measured ECoG signal was fabricated, and provided the desired function.

Research Products

• [Journal Article] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Michiyasu Suzuki, Masami Fujii, Toru Aoki
  • Journal Title: Advanced Materials Research Vol.222 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, S.Aou, S.Ishizuka, M.Suzuki, M.Fujii, T.Aoki
  • Journal Title: Advanced Materials Research Volume: Vol.222 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Application of Focal Cerebral Cooling for the Treatment of Intractable Epilepsy (2010)
  • Author(s): Masami Fujii, Hiroshi Fujioka, Takayuki Oku, Nobuhiro Tanaka, Hirochika Imoto, Yuichi Maruta, Sadahiro Nomura, Koji Kajiwara, Takashi Saito, Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki
  • Journal Title: Neurologia Medico-Chirurgica Vol.50, No.9 Pages: 839-844
  • NAID: 10030693779
  • Peer Reviewed
• [Journal Article] Epileptiform discharge inhibition using a multifunctional cryogenic microprobe for minimally invasive brain surgery (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Satoru Ishizuka, Zimin Lev Grigorievich, Michiyasu Suzuki, Masami Fujii
  • Journal Title: Memoirs of the Scientific Sections of the Romanian Academy Tome XXXIII Pages: 147-156
  • Peer Reviewed
• [Journal Article] Application of Focal Cerebral Cooling for the Treatment of Intractable Epilepsy (2010)
  • Author(s): Masami Fujii, Toshitaka Yamakawa, 他
  • Journal Title: Neurologia Medico-Chirurgica Volume: Vol.50 Pages: 839-844
  • NAID: 10030693779
  • Peer Reviewed
• [Journal Article] Epileptiform Discharge Inhibition Using a Multifunctional Cryogenic Microprobe for Minimally Invasive Brain Surgery (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, 他
  • Journal Title: Memoirs of the Scientific Sections of the Romanian Academy Volume: Tome XXXIII Pages: 147-156
  • Peer Reviewed
• [Journal Article] Epileptic Burst measurement Using Microelectrodes Equipped On A Cryogenic Microprobe for Minimally Invasive Brain Surgery of Intractable Epilepsy Treatment (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Satoru Ishizuka, Zimin Lev Grigorievich, Michiyasu Suzuki, Masami Fujii
  • Journal Title: Journal of Automation, Mobile Robotics & Intelligent Systems Vol.3, No.4 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Epileptic Burst measurement Using Microelectrodes Equipped On A Cryogenic Microprobe for Minimally Invasive Brain Surgery of Intractable Epilepsy Treatment (2009)
  • Author(s): Toshitaka Yamakawa, 他
  • Journal Title: Journal of Automation, Mobile Robotics & Intelligent Systems Vol. 3, No. 4 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Irreversible Blocking of Polar Excitations on Frog Sciatic Nerve Using Semiconductor Pulse Laser irradiation (2009)
  • Author(s): Yuya Hirayama, Toshitaka Yamakawa, 他
  • Journal Title: Journal of Automation, Mobile Robotics & Intelligent Systems Vol. 3, No. 4 Pages: 210-212
  • Peer Reviewed
• [Presentation] Epilepsy surgery employing smart metal and optical technologies (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Takao Inoue, Yuichi Maruta, Tatsuji Tokiwa, Toru Aoki, Masami Fujii, Michiyasu Suzuki
  • Organizer: International Workshop on Photonics and Bio-Medical Engineering 2010
  • Place of Presentation: Birmingham(イギリス)(招待講演)
  • Year and Date: 2010-12-15
• [Presentation] Epilepsy surgery employing smart metal and optical technologies (2010)
  • Author(s): Toshitaka Yamakawa
  • Organizer: International Workshop on Photonics and Bio-Medical Engineering 2010
  • Place of Presentation: アストン大学バーミンガム(イギリス)
  • Year and Date: 2010-12-15
• [Presentation] A Next-Generation Treatment of Epilepsy Employing Laser and Smart Metal Technologies As A Lifeboat Saving 68 Million Patients (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Takao Inoue, Yuichi Maruta, Michiyasu Suzuki, Masami Fujii, Toru Aoki
  • Organizer: 11th International Young Scientists Conference : Optics and High Technology Material Science
  • Place of Presentation: Kyiv(ウクライナ)(招待講演)
  • Year and Date: 2010-10-22
• [Presentation] A Next-Generation Treatment of Epilepsy Employing Laser and Smart Metal Technologies As A Lifeboat Saving 68 Million Patients (2010)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 11th International Young Scientists Conference : Optics and High Technology Material Science
  • Place of Presentation: キエフ国立大学キエフ(ウクライナ)
  • Year and Date: 2010-10-22
• [Presentation] Subdural Electrode Array Manipulated by a Shape Memory Alloy Guidewire for Minimally-invasive Electrocorticogram Recording (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Michiyasu Suzuki, Masami Fujii
  • Organizer: World Automation Congress 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-21
• [Presentation] Subdural Electrode Array Manipulated by a Shape Memory Alloy Guidewire for Minimally-invasive Electrocorticogram Recording (2010)
  • Author(s): Toshitaka Yamakawa
  • Organizer: World Automation Congress 2010
  • Place of Presentation: 神戸国際会議場神戸
  • Year and Date: 2010-09-21
• [Presentation] A Novel ECoG Recording Method Under a Minimally-Invasive Surgical Procedure Using the Shape-Memory-Alloy-Guided Subdural Microelectrodes (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Masami Fujii, Michiyasu Suzuki
  • Organizer: 4th Asian Epilepsy Surgery Congress
  • Place of Presentation: Taipei(台湾)
  • Year and Date: 2010-09-04
• [Presentation] A Novel ECoG Recording Method Under a Minimally-Invasive Surgical Procedure Using the Shape-Memory-Alloy-Guided Subdural Microelectrodes (2010)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 4th Asian Epilepsy Surgery Congress
  • Place of Presentation: 台北国際コンベンションセンター台北(台湾)
  • Year and Date: 2010-09-04
• [Presentation] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2010)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Shuji Aou, Satoru Ishizuka, Michiyasu Suzuki, Masami Fujii, Toru Aoki
  • Organizer: Inter-Academia 2010
  • Place of Presentation: Riga(ラトビア)
  • Year and Date: 2010-08-10
• [Presentation] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2010)
  • Author(s): Toshitaka Yamakawa
  • Organizer: Inter-Academia 2010
  • Place of Presentation: リガ工科大学 リガ(ラトビア)
  • Year and Date: 2010-08-10
• [Presentation] Cryo-Neurosurgery : A Novel Approach to the Treatment for Intractable Epilepsy (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Satoru Ishizuka, Zimin L. Grigorievich, Michiyasu Suzuki, Masami Fujii, Hiroshi Fujioka, Toru Aoki
  • Organizer: 10th International Young Scientists Conference : Optics and High Technology Material Science
  • Place of Presentation: Kyiv(ウクライナ)(招待講演)
  • Year and Date: 2009-10-24
• [Presentation] Cryo-Neurosurgery : A Novel Approach to the Treatment for Intractable Epilepsy (2009)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 10th International Young Scientists Conference : Optics and High Technology Material Science
  • Place of Presentation: キエフ (ウクライナ)
  • Year and Date: 2009-10-24
• [Presentation] Epileptic Burst measurement Using Microelectrodes Equipped On A Cryogenic Microprobe for Minimally Invasive Brain Surgery of Intractable Epilepsy Treatment (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Satoru Ishizuka, Zimin Lev Grigorievich, Michiyasu Suzuki, Masami Fujii
  • Organizer: Inter-Academia 2009
  • Place of Presentation: Kazimierz Dolny(ポーランド)
  • Year and Date: 2009-09-10
• [Presentation] Epileptogenic EEG Monitoring and Brain Stimulation Using A Multifunctional Microprobe for Minimally Invasive Brain Surgery (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki, Masami Fujii
  • Organizer: International Conference on electronics, Computers and Artificial Intelligence-ECAI'09
  • Place of Presentation: Pitesti(ルーマニア)
  • Year and Date: 2009-07-03
• [Presentation] A design of Low-Cost Minimally Invasice Surgical Instruments for Epileptogenic Intracranial EEG measurement and Brain Stimulation (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki, Masami Fujii
  • Organizer: 28th International Epilepsy Congress
  • Place of Presentation: Budapest(ハンガリー)
  • Year and Date: 2009-06-29
• [Presentation] IC-EEG measurement, Stimulation, and Freezing using A Multifunctional Microprobe for Minimally Invasive Cryosurgery (2009)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki, Masami Fujii, Zimin L. Grigorievich
  • Organizer: The 3rd Asian Epilepsy Surgery Congress
  • Place of Presentation: 大阪
  • Year and Date: 2009-06-18
• [Remarks] ホームページ等
  • URL: http://www.ipc.shizuoka.ac.jp/~ttyamak/
• [Remarks]
  • URL: http://www.ipc.shizuoka.ac.jp/~ttyamak/
• [Patent(Industrial Property Rights)] 配置システム、生体内計測装置及び制御方法 (2010)
  • Inventor(s): 山川俊貴、山川烈
  • Industrial Property Rights Holder: 九州工業大学
  • Industrial Property Number: 2010-013482
  • Filing Date: 2010
• [Patent(Industrial Property Rights)] 配置システム、生体内計測装置及び制御方法 (2010)
  • Inventor(s): 山川俊貴, 他
  • Industrial Property Rights Holder: 九州工業大学
  • Industrial Property Number: 2010-013482
  • Filing Date: 2010-01-25