| Project/Area Number |
21800056
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ISHIKAWA Taro 東京慈恵会医科大学, 医学部, 講師 (50547916)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 神経科学 / 生理学 / 薬理学 / 脳・神経 |
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| Research Abstract |
The frequency of action potential firing of mossy-fiber projecting neurons in the pontine nuclei and the trigeminal nuclei were investigated. In the slice preparation, neither the pontine cells nor trigeminal cells showed high-frequency firings exceeding 500 Hz. This finding was in striking contrast to the high-frequency firing of mossy fibers that had been observed in anaesthetized animals in vivo. Therefore, it is suggested that, in the in vivo preparation, a mechanism that enhances cellular excitability might have a significant effect.
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