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Metabolic analysis in Drosophila models of neurodegenerative diseases

Research Project

Project/Area Number 21800064
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionWaseda University

Principal Investigator

MATSUDA Nanami  Waseda University, 先端科学・健康医療融合研究機構, 講師 (70360641)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords神経変性疾患 / パーキンソン病 / 筋萎縮性軸索硬化症(ALS) / ショウジョウバエ / エネルギー代謝 / 病態モデル / 神経細胞死 / 老化
Research Abstract

There is increasing evidence that neurodegenerative diseases are a symptom of a deficiency in the regulation of mitochondrial function and metabolism, however the mechanism has been unclear. Mitochondria, as the central organelles in metabolic regulation might have a role to play in the common etiology of neurodegeneration. To address the roles of metabolic defect in neurodegenerative diseases, we established RNA interference-mediated Drosophila parkin (dparkin) knockdown flies and Drosophila ALS2/alsin (dALS2) knockdown flies, for Parkinson's disease and juvenile onset recessive familial amyotrophic lateral sclerosis (ALS2) models, respectively. We demonstrate that nervous system-specific knockdown of dparkin or dALS2 caused shorter lifespan and lower locomotor activity. Currently we are exploring the relevance of abnormality of metabolism and mitochondrial dysfunction in neurodegenerative pathogenesis caused by deficiency of parkin or ALS2.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009 Other

All Journal Article (1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] (増刊特集号・細胞死研究総集編)細胞競合の分子機構2010

    • Author(s)
      松田七美
    • Journal Title

      実験医学

      Volume: 28 Pages: 1111-1121

    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエを用いた神経変性疾患、及び老化モデルにおけるエネルギー代謝制御に関わる分子機構の解明2011

    • Author(s)
      堤香菜子、大野貴久、平本美香子、金井麻衣、合田亘人、松田七美
    • Organizer
      第4回早稲田大学・東京女子医科大学TWInsジョイントシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ワークショップ"組織構築とがん化を制御する細胞競合の分子機構":『癌関連遺伝子Mycを介した細胞競合の制御機構』2010

    • Author(s)
      松田七美
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸、兵庫県
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエの2型筋萎縮性側索硬化症モデルを用いたALS2/Alsinの機能解析2010

    • Author(s)
      堤香菜子、合田亘人、松田七美
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸、兵庫県
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic studies of age- and metabolism-related neurodegenerative diseases in Drosophila.2010

    • Author(s)
      Nanami Senoo-Matsuda
    • Organizer
      The 8th Joint Symposium between the University of Bonn and Waseda University
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of factors involved in competitive interactions during growth using a Drosophila cell-culture based assay system.2010

    • Author(s)
      Nanami Senoo-Matsuda, Laura A.Johnston, Nobuhito Goda
    • Organizer
      The 51st Annual Drosophila Research Conference
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエの2型筋萎縮性側索硬化症モデルを用いたALS2/Alsinの機能解析2010

    • Author(s)
      堤香菜子、合田亘人、松田七美
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経変性疾患ショウジョウバエモデルにおけるエネルギー代謝異常の解析2009

    • Author(s)
      金井麻衣, 堤香菜子, 合田亘人, 松田七美
    • Organizer
      第32回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経変性疾患ショウジョウバエモデルにおけるエネルギー代謝異常の解析2009

    • Author(s)
      金井麻衣、堤香菜子、合田亘人、松田七美
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.aoni.waseda.jp/nanami.s.matsuda/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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