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Mechanism of hematopoietic impairment due to abnormal zinc metabolism

Research Project

Project/Area Number 21800073
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionAichi Gakusen University

Principal Investigator

KONOMI Aki  Aichi Gakusen University, 家政学部, 講師 (40529658)

Research Collaborator YOKOI Katsuhiko  聖徳大学, 人間栄養学部, 教授 (10200883)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,392,000 (Direct Cost: ¥1,840,000、Indirect Cost: ¥552,000)
Fiscal Year 2010: ¥1,001,000 (Direct Cost: ¥770,000、Indirect Cost: ¥231,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords亜鉛 / 造血 / 栄養 / 鉄不応性貧血 / エリスロポエチン / 難治性造血障害 / 栄養学 / 貧血 / ゲノミクス
Research Abstract

Thirty 3-week-old male SD rats were assigned into 3 groups of 10 for the 4-week study. Difference between groups was statistically analyzed by Fisher's PLSD. P value less than 0.05 was considered significant. Plasma EPO concentration of zinc-deficient group was significantly decreased compared with control group, and pair-fed group was marginally decreased compared with control group (P=0.056). Kidney cortex EPO concentration was decreased in zinc-deficient group compared with pair-fed group. Kidney cortex EPO concentration in pair-fed group was higher than that of control group but the difference was not significant. No significant difference was observed in kidney medulla EPO concentration.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (31 results) Remarks (1 results)

  • [Journal Article] A possible role of plasma aldosterone in hypotension secondary to iron deficiency anaemia combined with zinc deficiency in rats.2011

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Journal Title

      British Journal of Nutrition. 105

      Pages: 535-538

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A possible role of plasma aldosterone in hypotension secondary to iron deficiency anaemia combined with zinc deficiency in rats.2011

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Journal Title

      British Journal of Nutrition.

      Volume: 105 Pages: 535-538

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of a modified hemoglobin regeneration efficiency method with a slope-ratio assay in measuring relative bioavailability of cocoa powder iron using rats.2011

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi, Miki Otagi.
    • Journal Title

      Biological Trace Element Research.

      Volume: DOI 10.1007/s12011-010-8953-1

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラットにおける飼料中ルビジウムと組織中ルビジウムの用量効果関係2010

    • Author(s)
      内田由佳、許斐亜紀、横井克彦
    • Journal Title

      微量栄養素研究(Trace Nutrients Research) 27

      Pages: 64-68

    • NAID

      40017445462

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ラットにおける飼料中ルビジウムと組織中ルビジウムの用量効果関係2010

    • Author(s)
      内田由佳、許斐亜起、横井克彦
    • Journal Title

      微量栄養素研究(Trace Nutrients Research).

      Volume: 27 Pages: 64-68

    • NAID

      40017445462

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron bioavailability of cocoa powder as determined by the Hb regeneration efficiency method.2009

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi, Miki Otagi
    • Journal Title

      British Journal of Nutrition. 102

      Pages: 215-220

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児における亜鉛の摂取上限量の検討-小児と亜鉛サプリメント-2009

    • Author(s)
      許斐亜紀
    • Journal Title

      ファルマシア 45(3)

      Pages: 269-270

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron bioavailability of cocoa powder as determined by the Hb regeneration efficiency method2009

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi, Miki Otagi
    • Journal Title

      British Journal of Nutrition Dec; 23

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of a modified hemoglobin regeneration efficiency method with a slope-ratio assay in measuring relative bioavailability of cocoa powder iron using rats.

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi, Miki Otagi
    • Journal Title

      Biological Trace Element Research.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 亜鉛欠乏下における腎臓中エリスロポエチン濃度の変化.Changes of Kidney Erythropoietin Concentration in Moderately Zinc-Deficient Rats. ミニシンポジウム病態・医薬品2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第21回日本微量元素学会(要旨集105頁)
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 食品中鉄の生物学的利用効率に関するバイオアッセイ. A bioassay for Iron Bioavailability in Foods.2010

    • Author(s)
      横井克彦、許斐亜紀、小田木美喜
    • Organizer
      第21回日本微量元素学会(要旨集115頁)
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 過剰量のルビジウムがラットの血漿生化学パラメーターに及ぼす影響2010

    • Author(s)
      内田由佳、許斐亜紀、横井克彦
    • Organizer
      第21回日本微量元素学会(要旨集123頁)
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛欠乏下における腎臓中エリスロポエチン濃度の変化.Changes of Kidney Erythropoietin Concentration in Moderately Zinc-Deficient Rats.2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第21回 日本微量元素学会ミニシンポジウム病態・医薬品
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食品中鉄の生物学的利用効率に関するバイオアッセイ.A bioassay for Iron Bioavailability in Foods2010

    • Author(s)
      横井克彦、許斐亜起、小田木美喜
    • Organizer
      第21回 日本微量元素学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過剰量のルビジウムがラットの血漿生化学パラメーターに及ぼす影響.Effect of excessive level of dietary rubidium on plasma biochemical parameters in rats.2010

    • Author(s)
      内田由佳、許斐亜紀、横井克彦
    • Organizer
      第21回 日本微量元素学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜鉛欠乏下における腎臓中ヘムオキシゲナーゼ-1濃度の変化2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第27回日本微量栄養素学会学術集会(要旨集16頁)
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2010-06-09
    • Related Report
      2010 Final Research Report
  • [Presentation] ラットにおける飼料中ルビジウムと組織中ルビジウムの用量効果関係の検討2010

    • Author(s)
      内田由佳、許斐亜紀、横井克彦
    • Organizer
      第27回日本微量栄養素学会学術集会(要旨集17頁)
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2010-06-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛欠乏下における腎臓中ヘムオキシゲナーゼ-1濃度の変化2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第27回 日本微量栄養素学会学術集会
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットにおける飼料中ルビジウムと組織中ルビジウムの用量効果関係の検討2010

    • Author(s)
      内田由佳、許斐亜紀、横井克彦
    • Organizer
      第27回 日本微量栄養素学会学術集会
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 重度鉄欠乏ラットに見られた血液生化学検査値の異常2010

    • Author(s)
      横井克彦、許斐亜紀、小田木美喜
    • Organizer
      第27回 日本微量栄養素学会学術集会
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜鉛欠乏下での造血障害発生メカニズムの解明-腎臓中HO-1濃度への影響-2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第64回日本栄養・食糧学会大会(要旨集109頁)
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 鉄欠乏ラットにみられた血液生化学検査値の異常2010

    • Author(s)
      横井克彦、許斐亜紀、小田木美喜
    • Organizer
      第64回日本栄養・食糧学会大会(要旨集110頁)
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛欠乏下での造血障害発生メカニズムの解明-腎臓中HO-1濃度への影響-2010

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第64回 日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鉄欠乏ラットにみられた血液生化学検査値の異常2010

    • Author(s)
      横井克彦、許斐亜紀、小田木美喜
    • Organizer
      第64回 日本栄養・食糧学会大会
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Changes of erythropoietin concentration in plasma and kidney induced by zinc deficiency.2010

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Organizer
      The FASEB JOURNAL(24:718.2.)
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Hemoglobin regeneration efficiency method revisited : an alternative bioassay for iron bioavailability.2010

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi, Miki Otagi
    • Organizer
      The FASEB JOURNAL(24:717.13.)
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes of erythropoietin concentration in plasma and kidney induced by zinc deficiency2010

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi.
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      アメリカ・カリフォルニア州・アナハイムコンベンションセンター
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hemoglobin regeneration efficiency method revisited : an alternative bioassay for iron bioavailability2010

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi. Miki Otagi.
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      アメリカ・カリフォルニア州・アナハイムコンベンションセンター
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜鉛および鉄欠乏ラットにおける速度論的亜鉛代謝指標の検討2009

    • Author(s)
      横井克彦、許斐亜紀
    • Organizer
      第20回日本微量元素学会
    • Year and Date
      2009-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛および鉄欠乏ラットにおける速度論的亜鉛代謝指標の検討2009

    • Author(s)
      横井克彦, 許斐亜紀
    • Organizer
      第20回 日本微量元素学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 亜鉛安定同位体を用いたラットの速度論的亜鉛代謝指標の測定2009

    • Author(s)
      横井克彦、許斐亜紀
    • Organizer
      第26回日本微量栄養素学会学術集会
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛安定同位体を用いたラットの速度論的亜鉛代謝指標の測定2009

    • Author(s)
      横井克彦, 許斐亜紀
    • Organizer
      第26回 日本微量栄養素学会学術集会
    • Place of Presentation
      京都リサーチパーク(京都府)
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鉄・亜鉛の同時もしくは単独欠乏が血液生化学検査値に及ぼす影響2009

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第63回日本栄養・食糧学会大会
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] ココア中鉄の生体利用性の測定-ヘモグロビン再生法の改良2009

    • Author(s)
      横井克彦、許斐亜紀、小田木美喜
    • Organizer
      第63回日本栄養・食糧学会大会
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 鉄・亜鉛の同時もしくは単独欠乏が血液生化学検査値に及ぼす影響2009

    • Author(s)
      許斐亜紀, 横井克彦
    • Organizer
      第63回 日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ココア中鉄の生体利用性の測定-ヘモグロビン再生法の改良2009

    • Author(s)
      横井克彦, 許斐亜紀, 小田木美喜
    • Organizer
      第63回 日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of iron and/or zinc deficiency on blood biochemical parameters in rats.2009

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Organizer
      The FASEB JOURNAL(23:921.13)
    • Year and Date
      2009-04-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of iron and/or zinc deficiency on blood biochemical parameters in rats2009

    • Author(s)
      許斐亜紀, 横井克彦
    • Organizer
      Experimental Biology 2009米国実験生物連合2009
    • Place of Presentation
      ルイ・アームストロングコンベンションセンター、ルイジアナ州、アメリカ合衆国
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Iron and zinc deficiencies affect zinc kinetic parameters in rats.2009

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi
    • Organizer
      The FASEB JOURNAL(23:216.7)
    • Year and Date
      2009-04-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Iron and zinc deficiencies affect zinc kinetic parameters in rats2009

    • Author(s)
      横井克彦, 許斐亜紀
    • Organizer
      Experimental Biology 2009米国実験生物連合2009
    • Place of Presentation
      ルイ・アームストロングコンベンションセンター、ルイジアナ州、アメリカ合衆国
    • Year and Date
      2009-04-20
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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