| Project/Area Number |
21800075
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
|---|
Principal Investigator |
URANO Yasuomi Doshisha University, 生命医科学部, 助教 (00546674)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 神経科学 / 脂質 / 痴呆 / アルツハイマー病 / 脂質代謝 / コレステロール / 細胞内輸送 / 酸化コレステロール |
|---|
| Research Abstract |
A major pathological hallmark of Alzheimer's disease is the accumulation of Amyloid β(Aβ) in senile plaques. Aβ is generated from Amyloid precursor protein (APP). In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, caused the inhibition of intracellular APP trafficking from endoplasmic reticulum to Golgi, resulting the reduction of Aβ production. In addition, several candidate proteins, which were associated with APP in the presence of 24S-hydroxycholesterol, were indentified.
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