| Project/Area Number |
21850020
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
MANDAI Hiroki Okayama University, 大学院・自然科学研究科, 助教 (60534427)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,665,000 (Direct Cost: ¥2,050,000、Indirect Cost: ¥615,000)
Fiscal Year 2010: ¥1,287,000 (Direct Cost: ¥990,000、Indirect Cost: ¥297,000)
Fiscal Year 2009: ¥1,378,000 (Direct Cost: ¥1,060,000、Indirect Cost: ¥318,000)
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| Keywords | 多成分連結反応 / 不斉求核触媒 / DMAP / 不斉触媒 / Petasis反応 / Ugi反応 / 不斉アシル化触媒 / 速度論的光学分割 / 有機触媒 / キラルDMAP |
|---|
| Research Abstract |
Diastereoselective Petasis reaction of 4-(dimethylamino)-2-pyridinecarbaldehyde was examined by using chiral amine. Diastereoselectivity was slightly observed. On the other hand, the Ugi reactions of 4-(dimethylamino)-3-pyridinecarbaldehydes with DMAP-based aldehyde, α-amino acid, and isocyanide, affording desired chiral DMAP catalyst with high diastereoselectivities. The kinetic resolution of secondary alcohols using thus obtained chiral DMAP is also examined.
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