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Study of well-defined oligosaccharide clusters for understanding their biomolecular recognition mechanisms

Research Project

Project/Area Number 21850029
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Polymer chemistry
Research InstitutionInstitute for Molecular Science

Principal Investigator

YAMAGUCHI Takumi  Institute for Molecular Science, 生命・錯体分子科学研究領域, 助教 (60522430)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,392,000 (Direct Cost: ¥1,840,000、Indirect Cost: ¥552,000)
Fiscal Year 2010: ¥1,118,000 (Direct Cost: ¥860,000、Indirect Cost: ¥258,000)
Fiscal Year 2009: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Keywords糖鎖 / 糖鎖集積 / NMR / 分子認識 / ランタノイド / 配位結合
Research Abstract

Oligosaccharides form clusters on cell membranes and thereby play unique and vital roles in various cellular events through interactions with biomolecules. For the elucidation of the underlying mechanisms of the glycocluster functions, systematic methods by using NMR spectroscopy were developed. This line of study can be extended to detailed analyses of structures, dynamics, and interactions of the sugar clusters on membranes.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Paramagnetic lanthanide tagging for NMR conformational analyses of N-linked oligosaccharides2011

    • Author(s)
      山本さよこ、山口拓実、Mate Erdelyi、Christian Griesinger、加藤晃一
    • Journal Title

      Chemistry -A European Journal (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] NMRによる糖鎖の立体構造解析のための新規手法の開発2011

    • Author(s)
      山口拓実
    • Organizer
      岡崎統合バイオサイエンスセンター10周年記念シンポジウム
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] NMR conformational analysis of N-linked oligosaccharides by paramagnetic tagging2011

    • Author(s)
      山口拓実
    • Organizer
      98^<th> Indian Science Congress
    • Place of Presentation
      SRM University(インド)
    • Year and Date
      2011-01-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] NMR spectroscopic approaches to the conformational characterization of N-linked oligosaccharides by introducing paramagnetic tags2010

    • Author(s)
      山口拓実
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      ハワイコンベンションセンター(アメリカ)
    • Year and Date
      2010-12-16
    • Related Report
      2010 Final Research Report
  • [Presentation] NMR spectroscopic approaches to the conformational characterization of N-linked oligosaccharides by introducing paramagnetic tags2010

    • Author(s)
      山口拓実
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      ハワイ コンベンションセンター(アメリカ)
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Paramagnetic-tagging approach for NMR characterization of N-linked oligosaccharides2010

    • Author(s)
      山口拓実
    • Organizer
      2^<nd> Asian Communications of Glycobiology and Glycotechnology (ACGG) conference
    • Place of Presentation
      Academia Sinica(台湾)
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 糖鎖のNMR構造解析のための新規手法の開発2010

    • Author(s)
      山口拓実
    • Organizer
      2009年度 生物物理学会中部支部講演会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development of NMR methods for structural analyses of oligosaccharides by using paramagnetic tags2009

    • Author(s)
      山口拓実
    • Organizer
      The 4th Winter School of JSPS Asian CORE Program for Frontiers of Materials, Photo-, and Theoretical Molecular Sciences
    • Place of Presentation
      ソウル国立大学(韓国)
    • Year and Date
      2009-12-14
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development of NMR conformational analysis methods for oligosaccharides by using paramagnetic metal ions2009

    • Author(s)
      山口拓実
    • Organizer
      SOKENDAI Asian Winter School 2009
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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