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Wearable chemical sensor for noninvasive biomonitering

Research Project

Project/Area Number 21860025
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKAHASHI Daishi  Tokyo Medical and Dental University, 生体材料工学研究所, 特任助教 (20549943)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,665,000 (Direct Cost: ¥2,050,000、Indirect Cost: ¥615,000)
Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsウエアラブルセンサ / 酸素センサ / グルコースセンサ / 生体計測 / ウエアラブル化学センサ / 生体計測技術 / フレキシブルセンサ
Research Abstract

In fabrication process of an oxygen sensor, electrodes were formed on a polypropylene membrane by sputtering system. And then, a porous membrane with an electrolyte solution was encapsulated using a polyethylene membrane, obtaining the flexible oxygen sensor. In the evaluation of the sensor characteristics, the output current linearly correlated with the concentrations of dissolved oxygen and gaseous oxygen. The sensor was applied to rabbit's eye. As a result, the change of the output current with an inhalation of a high level oxygen gas was observed. Furthermore, a flexible glucose sensor was fabricated by immobilizing an enzyme onto the sensing region of the electrode.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (22 results)

  • [Journal Article] Soft contact lens biosensor for in-situ monitoring of tear glucose as non-invasive blood sugar assessment2011

    • Author(s)
      Chu MX, Miyajima K, Takahashi D, Arakawa T, Sano K, Sawada S, Kudo H, Iwasaki Y, Akiyoshi K, Mochizuki M, Mitsubayashi K
    • Journal Title

      Talanta 83(3)

      Pages: 960-965

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft contact lens biosensor for in-situ monitoring of tear glucose as non-invasive blood sugar assessment2011

    • Author(s)
      CHU MX, MIYAJIMA K, TAKAHASHI D, ARAKAWA T, SANO K, SAWADA S, KUDO H, IWASAKI Y, AKIYOSHI K, MOCHIZUKI M, MITSUBAYASHI K
    • Journal Title

      Talanta

      Volume: 83 Pages: 960-965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soft-MEMS glucose sensor with functional polymers2010

    • Author(s)
      Iguchi S, Chu MX, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Journal Title

      Journal of Photopolymer Science and Technology 23(2)

      Pages: 167-170

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft-MEMS glucose sensor with functional Polymers2010

    • Author(s)
      IGUCHI S, CHU MX, TAKAHASHID, ARAKAWA T, KUDO H, MITSUBAYASHI K
    • Journal Title

      Journal of Photopolvmer Science and Technology

      Volume: 23 Pages: 167-170

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体適合性ポリマー材料を用いたフレキシブルグルコースセンサ2010

    • Author(s)
      平沼義貴, 初明星, 白井隆行, 高橋大志, 荒川貴博, 工藤寛之, 平松秀夫, 三林浩二
    • Organizer
      第57回応用物理学関係連合講演会
    • Place of Presentation
      平塚(神奈川)
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Contact lens type biosensor fabricated using MEMS techniques on biocompatible polymers for continuous monitoring of tear glucose2010

    • Author(s)
      Chu MX, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      20th Anniversary World Congress on Biosensors, BIOSENSORS2010
    • Place of Presentation
      Glasgow, UK
    • Related Report
      2010 Final Research Report
  • [Presentation] A wearable glucose sensor for non-invasive biomonitoring on eye site2010

    • Author(s)
      Chu MX, Iguchi S, Takahashi D, Hiranuma Y, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      the 13^<th> international meeting of chemical sensors (IMCS-13)
    • Place of Presentation
      Perth, Western Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of a contact-lens shaped biosensor for in-vivo tear glucose monitoring2010

    • Author(s)
      Kudo H, Chu MX, Hiranuma Y, Takahashi D, Arakawa T, Mitsubayashi K
    • Organizer
      The first Japan-China-Korea Joint Seminar on MEMS/NEMS 2010 for Green & Life Innovation
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Contact-lens type glucose sensor fabricated using Bionic-MEMS techniques for monitoring of tear sugar2010

    • Author(s)
      Mitsubayashi K, Chu MX, Takahashi D, Arakawa T, Kudo H
    • Organizer
      The 61st Annual Meeting of the International Society of Electrochemistry
    • Place of Presentation
      Nice, France
    • Related Report
      2010 Final Research Report
  • [Presentation] Contact lens type glucose sensor for continuous monitoring of tear sugar level2010

    • Author(s)
      Mitsubayashi K, Chu MX, , Hiranuma Y, Takahashi D, Arakawa T, Kudo H, Hiramatsu H
    • Organizer
      Pacificchem 2010
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 生体適合性ポリマー材料を用いたフレキシブルグルコースセンサ2010

    • Author(s)
      平沼義貴, 初明星, 白井隆行, 高橋大志, 荒川貴博, 工藤寛之, 平松秀夫, 三林浩二
    • Organizer
      第57回応用物理学関係連合講演会
    • Place of Presentation
      平塚
    • Related Report
      2010 Final Research Report
  • [Presentation] 涙液グルコースモニタリングのためのコンタクトレンズ型バイオセンサ2010

    • Author(s)
      初明星, 高橋大志, 荒川貴博, 工藤寛之, 秋吉一成, 三林浩二, 森本展行, 岩崎泰彦
    • Organizer
      第85回日本医療機器学会大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] ソフトコンタクトレンズ型バイオセンサを用いた涙液グルコース連続計測に関する研究2010

    • Author(s)
      荒川貴博, 初明星, 高橋大志, 工藤寛之, 森本展行, 岩崎泰彦, 秋吉一成, 三林浩二
    • Organizer
      2010年・秋季<第71回>応用物理学会学術講演会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体適合性ポリマーを用いたウエアラブルグルコースセンサに関する研究2010

    • Author(s)
      入江祐一, 矢野和義, 初明星, 平沼義貴, 平松秀夫, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
    • Organizer
      第22回SASインテリジェントシンポジウム
    • Place of Presentation
      平塚
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体適合性ポリマーを用いたアルコール用フレキシブルセンサ2010

    • Author(s)
      神白匠, 白井隆行, 矢野和義, 初明星, 平沼義貴, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
    • Organizer
      第22回SASインテリジェントシンポジウム
    • Place of Presentation
      平塚
    • Related Report
      2010 Final Research Report
  • [Presentation] Contact lens type biosensor fabricated using MEMS techniuues on biocompatible polymers for continuous monitoring of tear glucose2010

    • Author(s)
      Chu MX, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      20th Anniversary World Congress on Biosensors, BIOSENSORS2010
    • Place of Presentation
      Glasgow, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] A wearable glucose sensor for non-invasive biomonitoring on eye site2010

    • Author(s)
      Chu MX, Igucbi S, Takahashi D, Hiranuma Y, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      the 13^<th> international meeting of chemical sensors (IMCS-13)
    • Place of Presentation
      Perth, Western Australis
    • Related Report
      2010 Annual Research Report
  • [Presentation] Contact-lens type glucose sensor fabricated using Bionic-MEMS techniaues for monitoring of tear sugar2010

    • Author(s)
      Mitsubayashi K, Chu MX, Takahashi D, Arakawa T, Kudo H
    • Organizer
      The 61st Annual Meeting of the International Society of Electrochemistry
    • Place of Presentation
      Nice, France
    • Related Report
      2010 Annual Research Report
  • [Presentation] 涙液グルコースモニタリングのためのコンタクトレンズ型バイオセンサ2010

    • Author(s)
      初明星, 高橋大志, 荒川貴博, 工藤寛之, 秋吉一成, 三林浩二, 森本展行, 岩崎泰彦
    • Organizer
      第85回日本医療機器学会大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2010 Annual Research Report
  • [Presentation] ソフトコンタクトレンズ型バイオセンサを用いた涙液グルコース連続計測に関する研究2010

    • Author(s)
      荒川貴博, 初明星, 高橋大志, 工藤寛之, 森本展行, 岩崎泰彦, 秋吉一成, 三林浩二
    • Organizer
      2010年・秋季<第71同>応用物理学会学術講演会
    • Place of Presentation
      長崎県長崎市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体適合性ポリマーを用いたウエアラブルグルコースセンサに関する研究2010

    • Author(s)
      入江祐一, 矢野和義, 初明星, 平沼義貴, 平松秀夫, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
    • Organizer
      第22回SASインテリジェントシンポジウム
    • Place of Presentation
      神奈川県平塚市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体適合性ポリマーを用いたアルコール用フレキシブルセンサ2010

    • Author(s)
      神白匠, 白井隆行, 矢野和義, 初明星, 平沼義貴, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
    • Organizer
      第22回SASインテリジェントシンポジウム
    • Place of Presentation
      神奈川県平塚市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wearable Biosensor for Monitoring Tear Glucose on Rabbit Eye as Novel Device of Body Sensor Network2009

    • Author(s)
      Mitsubayashi K, Chu MX, Iguchi S, Takahashi D, Arakawa T, Kudo H
    • Organizer
      The Fifth International Conference on Intelligent Sensors, Sensor Networks and Information Processing ISSNIP 2009
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] A flexible sheet-type biosensor using biocompatible polymers2009

    • Author(s)
      Shirai T, Chu MX, Takahashi D, Arakawa T, Kudo H, Morimoto N, Yano K, Iwasaki Y, Akiyoshi K, Mitsubayashi K
    • Organizer
      8th Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 生体適合性ポリマーを用いたウエアラブルグルコースセンサ2009

    • Author(s)
      平沼義貴, 平松秀夫, 初明星, 白井隆行, 高橋大志, 荒川貴博, 工藤寛之, 三林浩二
    • Organizer
      第21回SASインテリジェントシンポジウム
    • Place of Presentation
      平塚(神奈川)
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 涙液グルコース計測を目的としたコンタクトレンズ型バイオセンサ2009

    • Author(s)
      初明星, 工藤寛之, 高橋大志, 荒川貴博, 秋吉一成, 三林浩二, 森本展行, 岩崎泰彦
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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