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a novel approach to create and characterize bone and bone marrow by the combination of tissue engineering and hematology

Research Project

Project/Area Number 21860051
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionKyoto University

Principal Investigator

KOHARA Hiroshi  Kyoto University, 医学研究科, 研究員 (40528733)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,678,000 (Direct Cost: ¥2,060,000、Indirect Cost: ¥618,000)
Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Fiscal Year 2009: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
Keywordsバイオマテリアル / ゼラチンハイドロゲル / 徐放 / 神経ペプチド / 血管新生 / 骨形成 / 加齢変化
Research Abstract

Angiogenesis was induced around the implanted site of gelatin hydrogels incorporating Substance P, a member of tachykinin family neuropeptides. In addition, accumulation of granulocytes, one of the circulating cells with angiogenic activities, around the implanted sites was observed. It is conceivable that the controlled release of SP efficiently induced the recruitment and the subsequent activation of granulocytes from the blood circulation into the site implanted, resulting in enhanced angiogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010

    • Author(s)
      Kohara H, Tajima S, Yamamoto M, Tabata Y.
    • Journal Title

      31巻

      Pages: 8617-8625

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenesis induced by controlled release of neuropeptide substance P2010

    • Author(s)
      Kohara H, Tajima S, Yamamoto M, Tabata Y
    • Journal Title

      Biomaterials

      Volume: 31 Pages: 8617-8625

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The controlled release of neuropeptide induces angiogenesis2010

    • Author(s)
      Kohara H., Yamamoto, M., Tabata Y
    • Organizer
      Biomedical Engineering Society 2010 Annual Meeting
    • Place of Presentation
      Austin Convention Center (米国テキサス州)
    • Related Report
      2010 Final Research Report
  • [Presentation] 徐放化神経ペプチドによる血管新生の誘導2010

    • Author(s)
      小原洋志、田畑泰彦
    • Organizer
      第31回日本炎症・再生医学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ゼラチンハイドロゲルを用いた神経ペプチド徐放システムによる血管新生誘導2010

    • Author(s)
      小原洋志、田畑泰彦
    • Organizer
      第39回医用高分子シンポジウム
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The controlled release of neuropeptide induces angiogenesis.2010

    • Author(s)
      Kohara, H., Yamamoto, M., Tabata, Y.
    • Organizer
      Biomedical Engineering Society 2010 Annual Meeting.
    • Place of Presentation
      Austin Convention Center (米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゼラチンハイドロゲルを用いた神経ペプチドの徐放による血管新生誘導2009

    • Author(s)
      小原洋志
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] ゼラチンハイドロゲルを用いた神経ペプチドの徐放による血管新生誘導2009

    • Author(s)
      小原洋志
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ (京都府)
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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