The role of b-TrCP in spermatogenesis.

• Project/Area Number: 21870006
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Tohoku University
• Principal Investigator: NAKANO Seiji Tohoku University, 大学院・医学系・研究科, 助手 (00529448)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000); Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000); Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
• Keywords: ユビキチンリガーゼ / 生殖細胞 / ノックアウトマウス / 不妊 / 雄生殖細胞 / タンパク質分解 / 幹細胞

Research Abstract

Spermatogonia-specific ss-TrCP knockout mice showed impairment of spermatogenesis. I observed reduction of the weight of testis to leb than 30% compared to that of control mice and histopathological abnormality with cavitation. On the other hand, sertoli cells specific knockout mice showed little effect on spermatogenesis. These data suggest that ss-TrCP play a critical role during spermatogenesis.

Research Products

• [Journal Article] Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines. (2011)
  • Author(s): Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimmura M, Kitano H
  • Journal Title: ORL J Otorhinolarygol Relat Spec Volume: 73 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Deleted in Esophageal Cancer 1 (DEC1) is down regulated and contributes to migration in HNSCC cell lines. (2010)
  • Author(s): Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimura M, Kitano H.
  • Journal Title: ORL J Otorhinolaryngol Relat Spec. 73 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas. (2010)
  • Author(s): H.Kataoka, et al
  • Journal Title: Yonago Acta Medica 52 Pages: 85-90
  • Peer Reviewed
• [Presentation] Geminin deletion in hematopoietic stem cells promotes differentiation of megakaryocytes and platelets. (2011)
  • Author(s): Seiji Nakano, Yousuke Sasaki, HozumiMotohashi, Keiko Nakayama.
  • Organizer: Winter Camp of GCOE 2011
  • Place of Presentation: 仙台
• [Presentation] Gemininは造血幹細胞の維持と巨核球の分化を制御する (2010)
  • Author(s): 中野星児, et al
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Geminin deletion in hematopoietic stem cells promotes differentiaton of megakaryocytes and platelets (2010)
  • Author(s): 中野星児、佐々木陽丞、本橋ほづみ、中山啓子
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] T-cell differentiation and proliferation in Geminin genedeleted mouse (2009)
  • Author(s): 中野星児, et al
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Chromobox homologue 3 is a essential modulator of endodermal and mesodermal differentiation in F9 cells (2009)
  • Author(s): 池田信人, et al
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Defect of T-cell differentiation and proliferation in Geminin gene-deleted mouse. (2009)
  • Author(s): 中野星児、山田秀俊、村井寛子、佐竹正延、中山啓子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Chromobox homologue 3 is a essential modulator of endodermal and mesodermal differentiation in F9 cells. (2009)
  • Author(s): 池田信人、森川久未、中野星児、久留一郎、白吉安昭
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Defect of T-cell differentiation and proliferation in Geminin gene-deleted mouse. (2009)
  • Author(s): Seiji Nakano, Hidetoshi Yamada, Hiroko Murai, Masanobu Satake, Keiko Nakayama.
  • Organizer: 東北大学グローバルCOE NetworkMedcine創生拠点国際シンポジウム
  • Place of Presentation: 仙台
• [Remarks] ホームページ等
• [Remarks] 東北大学医学系研究科細胞増殖制御分野
  • URL: http://www.devgen.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.devgen.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.devgen.med.tohoku.ac.jp/