The role of b-TrCP in spermatogenesis.
| Project/Area Number |
21870006
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKANO Seiji Tohoku University, 大学院・医学系・研究科, 助手 (00529448)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | ユビキチンリガーゼ / 生殖細胞 / ノックアウトマウス / 不妊 / 雄生殖細胞 / タンパク質分解 / 幹細胞 |
|---|
| Research Abstract |
Spermatogonia-specific ss-TrCP knockout mice showed impairment of spermatogenesis. I observed reduction of the weight of testis to leb than 30% compared to that of control mice and histopathological abnormality with cavitation. On the other hand, sertoli cells specific knockout mice showed little effect on spermatogenesis. These data suggest that ss-TrCP play a critical role during spermatogenesis.
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Report
(3 results)
Research Products
(15 results)
