| Project/Area Number |
21870011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ENDOU Daisuke Tokyo Medical and Dental University, 難治疾患研究所, 特任助教 (90516288)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | 胎盤 / レトロトランスポゾン / microRNA / 発生 / ゲノムインプリンティング / レローンスポゾン / ゲノムンプリンテング / アンチセンスRNA |
|---|
| Research Abstract |
In this study, I demonstrated the two essential role of AntiPeg11/Rtl1as, non-coding antisense RNA of Peg11/Rtl1. MicroRNAs derived from AntiPeg11/Rtl1as repress the expression of their sense RNA, Peg11Rtl1 as a siRNA and down regulate the angiogenesis in the placenta to avoid the placentomegaly. Moreover, these microRNAs also regulate the expression of their target genes as microRNAs and contribute to the normal development, embryonic growth, and the formation of sternum.
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