| Project/Area Number |
21870017
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
EBISUYA Miki Kyoto University, 医学研究科, 助教 (00544933)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | 遺伝子発現 / 網羅的解析 / 人工遺伝子回路 / 綱羅的解析 |
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| Research Abstract |
In this work, we analyzed and synthesized gene expression networks. The aim of the synthesis project is to create "artificial cell-cell communications". We designed small gene networks using the modified Notch pathway, transcription factors and cultured cells. So far, we have successfully made a system by which the neighboring cells mutually regulate each other's gene expression. In the analysis project, on the other hand, we studied the mechanism and generality of the "transcriptional ripple effect". The obtained results have suggested that the ripple effect occurs only at specific genomic locations and/or under specific cellular conditions.
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