Relationship of cytoplasmic capping to translation and cell stress
| Project/Area Number |
21870020
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
OTSUKA Yuichi Osaka University, 大学院・理学研究科, 助教 (10548861)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,574,000 (Direct Cost: ¥1,980,000、Indirect Cost: ¥594,000)
Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000)
Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000)
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| Keywords | mRNA / キャップ構造 / 細胞ストレス / 大腸菌 / T4ファージ / トキシン-アンチト / キシン / トキシン-アンチトキシン / キャップ構浩 / 翻訳 |
|---|
| Research Abstract |
The purpose of this research project is to verify that capping can occur in cytoplasm as well as nucleus, and show the significance of cytoplasmic capping in gene expression. I identified many target mRNAs to which cap structures would be added in cytoplasm. Also, deep sequencing analysis suggested that some of these mRNAs might have poly(U) tail at 3' terminus. These modifications on mRNA may play important roles in gene expression. In a different research project, I showed that bacteriophage T4 had an antitoxin against E.coli toxins for its own survival.
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Report
(3 results)
Research Products
(18 results)
