| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
|
|---|
| Research Abstract |
In order to understand how the stability of heterochromatin is ensured, we first produced a mutant which abolishes Lys9 methylation of histone H3 at 36℃. Analysis of this mutant indicated that the abolishment of heterochromatin requires cell cycle progression. Next, we performed a genetic screen and identified transcriptional regulators as factors that are responsible for the stability of heterochromatin. These results suggest that DNA replication and transcription are risk factors for heterochromatin instability.
|
