Regulation of the balance between proliferation and differentiation of neural progenitors in different histogenesis of brain.

• Project/Area Number: 21870030
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Kumamoto University
• Principal Investigator: HATAKEYAMA Jun Kumamoto University, 発生医学研究所, 助教 (90404350)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000); Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000); Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
• Keywords: 神経幹細胞 / 増殖 / 分化 / 脳 / 領域性 / Notch / 神経上皮 / イメージング / 境界細胞 / 組織構造

Research Abstract

Development of the central nervous system (CNS) requires an exquisite balance between proliferation and differentiation of the neural progenitors. The balance must be important for forming regional histogenesis. However the mechanisms remain poorly understood. Our results indicated that the apical endfeet of nascent neurons are important for regulating the balance. We suggest that the apical endfeet of neurons serve as a switch for neurogenesis, thereby regulating histogenesis of the CNS tissue.

Research Products

• [Journal Article] (2009)
  • Author(s): Ryoichiro Kageyama
  • Journal Title: Encyclopedia of Neuroscience(分担)(Oxford : Academic Press) Pages: 1057-1065
• [Journal Article] (2009)
  • Author(s): Jun Hatakeyama
  • Journal Title: Electroporation and Sonoporation in Developmental Biplogy(分担)(Springer) Pages: 43-54
• [Presentation] The adherens junction serve as a switch for neurogenesis by facilitating Notch-Delta interaction in the vertebrate CNS (2011)
  • Author(s): Jun Hatakeyama, Kenji Shimamura
  • Organizer: 第44回日本発生生物学会大会、口頭&ポスター発表
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
• [Presentation] 神経分化における接着帯の役割 (2010)
  • Author(s): 畠山淳
  • Organizer: 第6回宮崎サイエンスキャンプ
  • Place of Presentation: 宮崎ワールドコンベンションセンターサミット宮崎
  • Year and Date: 2010-02-26
• [Presentation] The adherens junction serves as a switch for neurogenesis via Notch signaling (2010)
  • Author(s): Jun Hatakeyama, Kenji Shimamura
  • Organizer: Notch and Stem Cells,ポスター発表
  • Place of Presentation: ionic centre, Athens, Greece.
• [Presentation] The adherens junction serves as a switch for neurogenesis (2010)
  • Author(s): Jun Hatakeyama, Kenji Shimamura
  • Organizer: 第43回日本発生生物学会 口頭発表&ポスター発表
  • Place of Presentation: 京都国際会館京都市
• [Presentation] 神経分化における接着帯の役割 (2010)
  • Author(s): 畠山淳
  • Organizer: 第6回宮崎サイエンスキャンプ ポスター発表
  • Place of Presentation: ワールドコンベンションセンターサミット宮崎市
• [Presentation] The adherens junction serves as a switch for neurogenesis (2010)
  • Author(s): Jun Hatakeyama
  • Organizer: 第43回日本発生生物学会
  • Place of Presentation: 京都国際会議場(京都市)
• [Presentation] The adherens junction serves as a switch for neurogenesis via Nocth signal (2010)
  • Author(s): Jun Hatakeyama
  • Organizer: The Notch meeting
  • Place of Presentation: Ionic center(ギリシャ)
• [Presentation] Role of the adherens junction in neurogenesis (2009)
  • Author(s): 畠山淳
  • Organizer: 第16回国際発生生物学会ISDB
  • Place of Presentation: 英国エディンバラ International Conference Center
  • Year and Date: 2009-09-08
• [Presentation] Novel boundary cells in the developing central nervous system (2009)
  • Author(s): 畠山淳
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟・朱鷺メッセ
  • Year and Date: 2009-05-30
• [Presentation] Role of the adherens junction in neurogenesis. (2009)
  • Author(s): Jun Hatakeyama, Kenji shimamura
  • Organizer: 16^<th> International Society of Developmental Biologists Congress 2009 ポスター発表
  • Place of Presentation: Edinburgh International Conference Centre, Edinburgh, UK
• [Presentation] Novel boundary cells in the developing central nervous system. (2009)
  • Author(s): Jun Hatakeyama, Kenji Shimamura
  • Organizer: 第42回日本発生生物学会 ポスター発表
  • Place of Presentation: 朱鷺メッセ新潟市
• [Presentation] A novel boundary in the developing central nervous system. (2009)
  • Author(s): 畠山淳
  • Organizer: 第3回神経発生討論会 ポスター発表
  • Place of Presentation: 岡崎コンファレンスセンター岡崎市愛知県
• [Book] Electroporation and Sonoporation in Developmental Biplogy(Method of electroporation for the early chick embryo) (2009)
  • Author(s): Hatakeyama J., Shimamura K.
  • Publisher: Springer
• [Book] Encyclopedia of Neuroscience.(Helix-loop-helix (bHLH) protein : Hes family.)Vol.4 (2009)
  • Author(s): Kageyama R, Ohtsuka T., Ohsawa R, Hatakeyama J
  • Publisher: Oxford : Academic Press.
• [Remarks] ホームページ
  • URL: http://www.imeg.kumamoto-u.ac.jp/divisions/morphogenesis/