Peptidome analysis focusing on C-terminal amidation : Identification and functional analysis of novel bioactive peptides.
| Project/Area Number |
21870055
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
WAKABAYASHI Masaki 独立行政法人国立循環器病研究センター, 分子薬理部, 研究員 (70552024)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | 生理活性ペプチド / ペプチドーム解析 / C末端アミド化 / 抗体アフィニティーカラム |
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| Research Abstract |
Bioactive peptides play crucial roles in complex homeostasis regulatory systems in living organisms. Thus, it is essential to identify novel bioactive peptides and analyze their physiological functions to elucidate the homeostasis regulatory systems. In this study, we tried to isolate new bioactive peptides using their frequently observed structural characteristic, C-terminal amidation, as a hallmark. We developed a method for condensation of C-terminally amidated peptides from naturally occurring peptide mixtures, though a novel bioactive peptide was not identified.
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Report
(3 results)
Research Products
(2 results)
