| Project/Area Number |
21880002
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
ICHII Osamu Hokkaido University, 大学院・獣医学研究科, 助教 (60547769)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
|
|---|
| Keywords | バイオマーカー / 尿 / 慢性腎臓病 / 伴侶動物 / mRNA / microRNA / 糸球体傷害 / 尿細管間質病変 / Luminal Epithelial Deciduation (LED) / 慢性腎臓病(CKD) / PCRarray/microarray / 糸球体上皮細胞傷害 / mRNA/microRNA / イヌ/ネコ / 管腔上皮脱落(LED) / 疾患モデルマウス / Interleukin 1 family member 6 / mRNA・microRNA / PCRarray・microarray |
|---|
| Research Abstract |
This study clarified that the renal parenchymal cells were dropped into urine in renal pathological conditions. The quantitative and qualitative urinary cellular patterns correlated with the deteriorations of renal pathology and function in renal disease models and companion animals. Importantly, these urinary cells could be detected by molecular biological methods targeting mRNA and microRNA in urine. These data indicated the possibility that the urinary tests based on the detections of urinary cells, entitled "Urinary Molecular Profiling" in the present study, could be noninvasive diagnosis methods for renal disease.
|
