| Project/Area Number |
21880003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIYAZAKI Satoshi Hokkaido University, 大学院・獣医学研究科, 博士研究員 (20547781)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | アフリカ睡眠病 / トリパノソーマ / ツェツェバエ / 分化制御因子 / サシバエ / 遺伝子重複 / RACE法 / セリンプロテアーゼ / Glossina proteolytic lectin / Trypanosoma vivax / Glossina morsitans / Variable Surface Glycoprotein / トリプシン / キモトリプシン / ノサシバエ |
|---|
| Research Abstract |
To control the African Sleeping Sickness, which is caused by the infection of trypanosome parasites (Trypanosoma spp.) into mammalian blood, it is required to understand the regulatory mechanisms for cell differentiation into insect form parasite at the timing of infection. In this study, the full length of Glossina serine protease 1 (Gsp1) was isolated by RACE PCR as the candidate of regulatory molecules, and it was showed that Gsp1 have the trypsin-like serine protease domain. Considering the previous studies, one of the serine protease genes duplicated might gain the novel function for controlling the insect-form transformation of Trypanosoma. I
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