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Control mechanisms of angiogenesis in the developing corpus luteum in the cow : local regulation by VEGF-Vasohibin

Research Project

Project/Area Number 21880006
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied animal science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

KOUMEI Shirasuna  Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 助教 (20552780)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywordsウシ / 血管新生 / 繁殖生理 / 黄体
Research Abstract

Establishment of pregnancy is basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has key role to establish pregnancy. The aim of the present study is the elucidation of molecular mechanisms about development of the bovine corpus luteum, and the presentation a vision of developing technologies for improvement of conception rate in the cow.
From the results of the present study, we clearly demonstrated that VEGF-Vasohibin system exists in the bovine corpus luteum. Also, VEGF stimulated vasohibin expression and vasohibin inhibited angiogenesis induced by VEGF in vitro cell culture model. These findings suggest that vasohibin has a potential to control angiogenesis with the proper level in the developing corpus luteum in the cow.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Prostaglandin F_<2a> differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow.2010

    • Author(s)
      Shirasuna K, Sasahara K, Matsui M, Shimizu T, Miyamoto A.
    • Journal Title

      J Reprod Dev 56

      Pages: 428-436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F_<2α> differentially affects mRNA expression relating to angiogenesis, vacoactivation and prostaglandins in the early and mid corpus luteum in the cow2010

    • Author(s)
      Shirasuna K, Sasahara K, Matsui M, Shimizu T., Miyamoto A.
    • Journal Title

      Journal or Reproduction and Development

      Volume: 56 Pages: 428-436

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of arteriolovenous vessels, capillaries and eNOS expression in the bovine corpus luteum during the estrous cycle : a possible implication of different sensitivity by luteal phase to PGF_<2α> in the increase of luteal blood flow2010

    • Author(s)
      Shirasuna K, Asahi T, Sasaki M, Shimizu T, Miyamoto A.
    • Journal Title

      Journal of Reproduction and Development 56

      Pages: 123-130

    • NAID

      10026323838

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F_<2α> differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow2010

    • Author(s)
      Shirasuna K, Sasahara K, Matsui M, Shimizu T, Miyamoto A.
    • Journal Title

      Journal or Reproduction and Development (In press)

    • NAID

      10026621723

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of corpus luteum development and maintenance : specific roles of angiogenesis and action of Prostaglandin F_2a2010

    • Author(s)
      A.Miyamoto,K.Shirasuna T.Shimizu, H.Bollwein, D.Schams
    • Organizer
      8st International Ruminant Reproduction Symposium
    • Place of Presentation
      Anchorage, Alaska, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウシ黄体でのVEGF-Vasohibinシステムの発現と調節2009

    • Author(s)
      小林明由未
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      奈良・近畿大学
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] A novel concept for the bovine luteolytic cascade with a focus on luteal blood flow and vasoactive factors2009

    • Author(s)
      Shirasuna K, Shimizu T, Matsui M, Miyamoto A.
    • Organizer
      日本繁殖生物学会 日韓シンポジウム
    • Place of Presentation
      奈良・近畿大学
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vasohibin expression in the bovine corpus luteum : Regulation by VEGF and prostaglandin F2α.2009

    • Author(s)
      Shirasuna K
    • Organizer
      42^<nd> Annual Meeting, Society for Study of Reproduction(SSR)
    • Place of Presentation
      David L.Lawrenceコンベンションセンター(ペンシルバニア・ピッツバーグ)
    • Year and Date
      2009-07-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vasohibin expression in the bovine corpus luteum : Regulation by VEGF and prostaglandin F_<2a>2009

    • Author(s)
      Shirasuna K, Sasahara K, Akabane Y, Matsui M, Meidan R, Shimizu T, Miyamoto A.
    • Organizer
      42^<th> annual meeting ; Society for the Study of Reproduction.
    • Place of Presentation
      Pennsylvania (USA)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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