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Breaking immunological tolerance to canine malignant melanoma by inhibition of Gpnmb expression : a new approach for melanoma immunotherapy

Research Project

Project/Area Number 21880008
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

TOMIHARI Mizuki  Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 助教 (00552754)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywords獣医学 / 臨床 / 癌 / 免疫学 / 生体分子 / 犬 / 腫瘍 / 悪性黒色腫 / 免疫療法
Research Abstract

Gpnmb is a negative regulator of T lymphocyte activation, and also a tumor-associated antigen in melanoma. We identified the cDNA sequence of canine Gpnmb, and it showed high mRNA expression of Gpnmb in two canine melanoma cell lines. Furthermore, Gpnmb mRNA level was much higher than the other well-known negative regulators in melanoma tissues of dogs. These results suggested that Gpnmb was specifically expressed in canine melanoma and a most important negative regulator among the others.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.2010

    • Author(s)
      Tomihari M, Chung JS, Akiyoshi H, Cruz PD, Jr, Ariizumi K.
    • Journal Title

      Cancer Res. 70(14)

      Pages: 5778-87

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand : a new opportunity for treating activated T cell-driven disease.2010

    • Author(s)
      Akiyoshi H, Chung JS, Tomihari M, Cruz PD, Jr, Ariizumi K.
    • Journal Title

      J Immunol. 184(7)

      Pages: 3554-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.2010

    • Author(s)
      Tomihari M, ほか4名
    • Journal Title

      Cancer Res.

      Volume: 70(14) Pages: 5778-5787

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depleting syndecan-4+ T lymphooytes usingt toxin-bearing dendritic cell-associated heparan suifate protenglycan-depedent integrin ligand:a new opportunity for treating activated T cell-driven disease.2010

    • Author(s)
      Akiyoshi H, Chung JS, Tomihari M, ほか2名
    • Journal Title

      J Immunol.

      Volume: 184(7) Pages: 3554-3561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function.2009

    • Author(s)
      Chung JS, Yudate T, Tomihari M, Akiyoshi H, Cruz PD, Jr, Ariizumi K.
    • Journal Title

      J Immunol. 183(8)

      Pages: 5190-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses.2009

    • Author(s)
      Chung JS, Bonkobara M, Tomihari M, Cruz PD, Jr, Ariizumi K.
    • Journal Title

      Eur J Immunol. 39(4)

      Pages: 965-74

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion.2009

    • Author(s)
      Tomihari M, Hwang SH, Chung JS, Cruz PD, Jr, Ariizumi K.
    • Journal Title

      Exp Dermatol. 18(7)

      Pages: 586-95

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-denendent fashion.2009

    • Author(s)
      Tomihari M, ほか4名
    • Journal Title

      Exp Dermatol. 18(7)

      Pages: 586-595

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell response.2009

    • Author(s)
      Chung JS, Tomihari M, ほか3名
    • Journal Title

      Eur J Immunol. 39(4)

      Pages: 965-974

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function.2009

    • Author(s)
      Chung JS, Tomihari M, ほか4名
    • Journal Title

      J Immunol. 183(8)

      Pages: 5190-5198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Syndecan-4 is an important negative regulator of T cell immunity and a potentially useful target for treating diseases resulting from such immunity.2010

    • Author(s)
      Chung JS, Tomihari M, Akiyoshi H, Cruz PD, Jr, Ariizumi K
    • Organizer
      Society for Investigative Dermatology, 70^<th> annual meeting
    • Place of Presentation
      Atlanta, Georgia, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Syndecan-4 is an important negative regulator of T cell immunity and a potentially useful target for treating diseases resulting from such immunity2010

    • Author(s)
      Chung JS, Tbmihar M, ほか3名
    • Organizer
      Society for Investigative Dermatology 70^<th> annual meeting
    • Place of Presentation
      Atlanta, Georgia, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exploiting the DC-HIL/syndecan-4 pathway to treat cutaneous T cell lymphoma.2009

    • Author(s)
      Chung JS, Yudate T, Tomihari M, Cruz PD, Jr, Ariizumi K
    • Organizer
      Society for Investigative Dermatology, 69^<th> annual meeting
    • Place of Presentation
      Montreal, Canada, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Exploiting the DC-HIL/syndecan-4 pathway to treat cutaneous T cell lymphoma2009

    • Author(s)
      Chung JS, Tomihari M, ほか4名
    • Organizer
      Society for Investigative Dermatology, 69^<th> annual meeting
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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