Synthetic and SAR studies of alchivemycin, novel antibacterial and antitumor polyketide
| Project/Area Number |
21880012
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
ENOMOTO Masaru Tohoku University, 大学院・農学研究科, 助教 (90546342)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,769,000 (Direct Cost: ¥2,130,000、Indirect Cost: ¥639,000)
Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Fiscal Year 2009: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
|
|---|
| Keywords | 有機合成化学 / 天然物化学 / 全合成 / alchivemycin / tetrahydro-1 / 2-oxazine-3 / 5-dione / tetrahydro-1,2-oxazine-3,5-dione / paspalicine / lupinacidin / malyngic acid / fulgidic acid / thiersinine / pachastrissamine / jaspine |
|---|
| Research Abstract |
Alchivemycins possessing unprecedented framework exhibit antibacterial and antitumor activities. A model compound of alchivemycin core, unprecedented tetrahydro-1,2-oxazine-3,5-dione moiety, has been synthesized.
|
Report
(3 results)
Research Products
(35 results)
