• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthetic and SAR studies of alchivemycin, novel antibacterial and antitumor polyketide

Research Project

Project/Area Number 21880012
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionTohoku University

Principal Investigator

ENOMOTO Masaru  Tohoku University, 大学院・農学研究科, 助教 (90546342)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,769,000 (Direct Cost: ¥2,130,000、Indirect Cost: ¥639,000)
Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Fiscal Year 2009: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
Keywords有機合成化学 / 天然物化学 / 全合成 / alchivemycin / tetrahydro-1 / 2-oxazine-3 / 5-dione / tetrahydro-1,2-oxazine-3,5-dione / paspalicine / lupinacidin / malyngic acid / fulgidic acid / thiersinine / pachastrissamine / jaspine
Research Abstract

Alchivemycins possessing unprecedented framework exhibit antibacterial and antitumor activities. A model compound of alchivemycin core, unprecedented tetrahydro-1,2-oxazine-3,5-dione moiety, has been synthesized.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (14 results) Remarks (3 results)

  • [Journal Article] Stereoselective Synthesis of Malyngic acid and Fulgidic acid2011

    • Author(s)
      Yusuke, Kurashina, Ayako Miura, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron. vol.67

      Pages: 1649-1653

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lupinacidin C, an Inhibitor of Tumor Cell Invasion from Micromonospora lupini2011

    • Author(s)
      Yasuhiro Igarashi, Saeko Yanase, Kohei Sugimoto, Masaru Enomoto, Satoshi Miyanaga, MarthaE. Trujillo, Ikuo Saiki, Shigefumi Kuwahara
    • Journal Title

      J.Nat.Prod. vol.74

      Pages: 862-865

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lupinacidin C, an Inhibitor of Tumor Cell Invasion from Micromonospora lupini2011

    • Author(s)
      Yasuhiro Igarashi, Saeko Yanase, Kohei Sugimoto, Masaru Enomoto, Satoshi Miyanaga, MarthaE. Trujillo, Ikuo Saiki, Shigefumi Kuwahara
    • Journal Title

      Journal of Natural Products

      Volume: 74 in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of Malyngic acid and Fulgidic acid2011

    • Author(s)
      Yusuke Kurashina, Ayako Miura, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 1649-1653

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial Racemization Occurring in the Hydroxylactonization of a δ, ε-Epoxy Amide2010

    • Author(s)
      Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry vol.74

      Pages: 2535-2537

    • NAID

      10027728546

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expeditious Construction of the DEF Ring System of Thiersinine B2010

    • Author(s)
      Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      The Journal of Organic Chemistry vol.75

      Pages: 6286-6289

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of lupinacidins A and B via sequential cycloaddition-double elimination2010

    • Author(s)
      Kohei Sugimoto, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron Letters vol.51

      Pages: 4570-4572

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of pachastrissamine and jaspine A via hydroxylactonization of a chiral epoxy ester2010

    • Author(s)
      Hiroyuki Urano, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry vol.74

      Pages: 152-157

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特異な複素環構造を有するバシロサルシンA,Bおよび関連化合物の合成研究2010

    • Author(s)
      榎本賢,桑原重文
    • Journal Title

      有機合成化学協会誌 vol.68

      Pages: 387-398

    • NAID

      10026868671

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expeditious Construction of the DEF Ring System of Thiersinine B2010

    • Author(s)
      Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 75 Pages: 6286-6289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial Racemization Occurring in the Hydroxylactonization of a δ, ε-Epoxy Amide2010

    • Author(s)
      Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 74 Pages: 2535-2537

    • NAID

      10027728546

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特異な複素環構造を有するバシロサルシンA, Bおよび関連化合物の合成研究2010

    • Author(s)
      榎本賢、桑原重文
    • Journal Title

      有機合成化学協会誌

      Volume: 68 Pages: 387-398

    • NAID

      10026868671

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Lupinacidins A and B via Sequential Cycloaddition-Double Elimination2010

    • Author(s)
      Kohei Sugimoto, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Tetrahedron Letters

      Volume: 51 Pages: 4570-4572

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of pachastrissamine and jaspine A via hydoxylactonization of a chiral epoxy ester2010

    • Author(s)
      Hiroyuki Urano, Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 74

      Pages: 152-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise Synthesis of PM-94128 and Y-05460M-A2009

    • Author(s)
      Masaru Enomoto, Shigefumi Kuwahara
    • Journal Title

      The Journal of Organic Chemisty vol.74

      Pages: 7566-7569

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] きわめて特異な複素環構造を有するバシロサルシンAおよびBの全合成2009

    • Author(s)
      榎本賢、桑原重文
    • Journal Title

      化学と生物 vol.47

      Pages: 804-808

    • NAID

      10026437025

    • Related Report
      2010 Final Research Report
  • [Journal Article] 極めて特異な複素環構造を有するバシロサルシンA,Bの全合成2009

    • Author(s)
      榎本賢, 桑原重文
    • Journal Title

      化学と生物 47

      Pages: 804-808

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Concise synthesis of PM-94128 and Y-05460M-A2009

    • Author(s)
      榎本賢, 桑原重文
    • Journal Title

      The Journal of Organic Chemistry 74

      Pages: 7566-7569

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗HIV活性を有する4'Ed2FAの合成研究2011

    • Author(s)
      陰山真将、吉田真弓、永沢友裕、榎本賢、桑原重文
    • Organizer
      日本農芸化学会2011年度大会(震災により講演要旨集発行のみによる成立)
    • Place of Presentation
      京都
    • Year and Date
      2011-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Malyngic acid および12-epi-malyngic acid の合成研究2011

    • Author(s)
      倉科友輔、三浦絢子、永沢友裕、榎本賢、桑原重文
    • Organizer
      日本農芸化学会2011年度大会(震災により講演要旨集発行のみによる成立)
    • Place of Presentation
      京都
    • Year and Date
      2011-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗HIV活性を有する4'Ed2FAの合成研究2011

    • Author(s)
      陰山真将、吉田真弓、永沢友裕、榎本賢、桑原重文
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都(震災により講演要旨集発行のみによる成立)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Malyngic acidおよび12-epi-malyngic acidの合成研究2011

    • Author(s)
      倉科友輔、三浦絢子、永沢友裕、榎本賢、桑原重文
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都(震災により講演要旨集発行のみによる成立)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thiersinine AおよびBの合成研究2010

    • Author(s)
      榎本賢,森田暁,桑原重文
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Thiersinine AおよびBの全合成研究2010

    • Author(s)
      榎本賢、森田暁、桑原重文
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗HIV活性を有する4'Ed2FAの合成研究2010

    • Author(s)
      陰山真将,吉田真弓,永沢友裕,榎本賢,桑原重文
    • Organizer
      日本農芸化学会東北支部第145回大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Malyngic acidおよび12-epi-malyngic acidの合成研究2010

    • Author(s)
      倉科友輔,三浦絢子,永沢友裕,榎本賢,桑原重文
    • Organizer
      日本農芸化学会東北支部第145回大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 細胞毒性物質Sg17-1-4の合成研究2010

    • Author(s)
      小関良卓,會之緯,榎本賢,桑原重文
    • Organizer
      日本農芸化学会東北支部第145回大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 殺虫活性物質thiersinine AおよびBの合成研究2010

    • Author(s)
      榎本賢,森田暁,桑原重文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] がん細胞浸潤阻害活性物質ルピナシジン類の合成研究2010

    • Author(s)
      杉本浩平,榎本賢,桑原重文
    • Organizer
      日本農芸化学会 2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] がん細胞浸潤阻害活性物質ルピナシジン類の合成研究2010

    • Author(s)
      杉本浩平、榎本賢、桑原重文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lupinacidin AおよびBの合成研究2009

    • Author(s)
      杉本浩平,榎本賢,桑原重文
    • Organizer
      日本農芸化学会東北支部第144回大会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] PM-94128の全合成およびY-05460MAの立体化学決定2009

    • Author(s)
      榎本賢, 桑原重文
    • Organizer
      日本農芸化学会東北支部第144回大会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.agri.tohoku.ac.jp/yuuki/index-j.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/yuuki/index-j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/yuuki/index-j.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi