Molecular dissection of salicylic acid signaling in systemic acquired resistance

• Project/Area Number: 21880033
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Plant pathology
• Research Institution: Kagawa University
• Principal Investigator: TADA Yasuomi Kagawa University, 総合生命科学研究センター, 准教授 (40552740)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000); Fiscal Year 2009: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
• Keywords: サリチル酸 / 全身獲得抵抗性 / 複合体解析 / シロイヌナズナ / 植物病理学

Research Abstract

NPR1 protein is the key transcription coactivator in salicylic acid (SA) signaling. Although the formation of NPR1 oligomer is prerequisite for its activation, the molecular mechanism is not fully elucidated. Here we have identified EF-Tu as a member of NPR1 complex in planta. We found that EF-Tu is involved in the stabilization of NPR1 oligomer, and disease resistance against Pseudomonas syringae. It is strongly suggested that EF-Tu is a positive regulator of SA-mediated signaling.

Research Products

• [Journal Article] Timing of plant immune responses by a central circadian regulator (2011)
  • Author(s): W.Wang, J.Y. Barnaby, Y.Tada, H.Li, M.Tor, D.Caldelari, D.Lee, X.D.Fu, X.Dong
  • Journal Title: Nature 470 Pages: 110-114
  • Peer Reviewed
• [Journal Article] Timing of plant immune responses by a central circadian regulator (2011)
  • Author(s): Wang W
  • Journal Title: Nature Volume: 470 Pages: 110-114
  • Peer Reviewed
• [Journal Article] Post-translational modification as a tool for transcription reprogramming (2010)
  • Author(s): S.H.Spoel, Y.Tada, G.J.Loake
  • Journal Title: New Phytol. 186 Pages: 333-339
  • Peer Reviewed
• [Journal Article] A rare sugar, D-allose, confers resistance to rice bacterial blight with upregulation of defense-related genes in Oryza sativa L. (2010)
  • Author(s): Kano, A., Gomi, K., Yamasaki-Kokudo, Y., Satoh, M., Fukumoto, T., Ohtani, K., Tajima, S., Izumori, K., Tanaka, K., Ishida, Y., Tada, Y., Nishizawa, Y., Akimitsu, K.
  • Journal Title: Phytopathology 100 Pages: 85-90
  • Peer Reviewed
• [Journal Article] ACTTS3 encoding a polyketide synthase is essential for the biosynthesis of ACT-toxin and pathogenicity in the tangerine pathotype of Alternaria alternata. (2010)
  • Author(s): Miyamoto, Y., Masunaka, A., Tsuge, T., Yamamoto, M., Ohtani, K., Fukumoto, T., Gomi, K., Peever, T.L., Tada, Y., Ichimura, K., Akimitsu, K.
  • Journal Title: Molecular Plant-Microbe Interaction 23 Pages: 406-414
  • Peer Reviewed
• [Journal Article] Role of the host-selective ACT-toxin synthesis gene ACTTS2 encoding an enoyl-reductase in pathogenicity of the tangerine pathotype of Alternaria alternata. (2010)
  • Author(s): Ajiro, N., Miyamoto, Y., Masunaka, A., Tsuge, T., Yamamoto, M., Ohtani, K., Fukumoto, T., Gomi, K., Peever, T.L., Izumi, Y., Tada, Y., Akimitsu, K.
  • Journal Title: Phytopathology 100 Pages: 120-126
  • Peer Reviewed
• [Journal Article] Genome-enabled Evaluation of Specificity in Citrus and Alternaria Interactions. (2010)
  • Author(s): Akimitsu, K., Miyamoto, Y., Ohtani, K., Masunaka, A., Izumi, Y., Yasuda, S., Nishida, S., Fukumoto, T., Ishimoto, T., Kano, A., Katoh, H., Saitoh, M., Tada, Y., Ichimura, K., Gomi, K.
  • Journal Title: Genome-Enabled Analysis of Plant-Pathogen Interactions, T. Wolpert et al. eds. APS press, in press
  • Peer Reviewed
• [Journal Article] Role of rare sugars in plant-microbe interactions. (2010)
  • Author(s): Akimitsu, K., Kano, A., Fukumoto, T., Ohtani, K., Gomi, K., Ichimura, K., Tada, Y., Tajima, S., Izumori, K.
  • Journal Title: The 3rd Joint Symposium between CMU and KU Pages: 16-17
  • Peer Reviewed
• [Journal Article] Post-translational protein modification as a tool for transcription reprogramming (2010)
  • Author(s): Spoel SH
  • Journal Title: New Phytologist Volume: 186 Pages: 333-339
  • Peer Reviewed
• [Journal Article] Proteasome-mediated turnover of the transcription co-activator NPR1 plays dual roles in regulating plant immunity (2009)
  • Author(s): S.H.Spoel, Z.Mou, Y.Tada, N.Spivey, P.Genschik, X.Dong
  • Journal Title: Cell 137 Pages: 860-872
  • Peer Reviewed
• [Journal Article] Molecular Cloning and Characterization of a Thaumatin-like Protein-encoding cDNA from Rough Lemon. (2009)
  • Author(s): Kim, B.G., Fukumoto, T., Tatano, S., Gomi, K., Ohtani, K., Tada, Y., Akimitsu, K.
  • Journal Title: Physiological and Molecular Plant Pathology 74 Pages: 3-10
  • Peer Reviewed
• [Journal Article] Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity (2009)
  • Author(s): Spoel SH
  • Journal Title: Cell 137巻 Pages: 860-872
  • Peer Reviewed
• [Presentation] Redox regulation of NPR1 requires NOC protein in plant immunity (2010)
  • Organizer: Proceedings of 21st International Conference on Arabidopsis Research
  • Place of Presentation: Pacifico Yokohama, Kanagawa, Japan
  • Year and Date: 2010-06-08
• [Presentation] Redox regulation of NPR1 requires NOC protein in plant immunity (2010)
  • Author(s): Nodoka Oka
  • Organizer: 21^<st> International conference on Arabidopsis research
  • Place of Presentation: Pacifico Yokohama,Kanagawa, Japan
  • Year and Date: 2010-06-08
• [Presentation] サリチル酸依存的シグナルネットワークにおけるタンパク質翻訳後修飾の役割 (2010)
  • Organizer: 植物病理学会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-19
• [Presentation] The redox and proteolysis-coupled transcription cycles regulate the salicylic acid signaling (2010)
  • Author(s): 多田安臣
  • Organizer: 第51回日本植物生理学会年会
  • Place of Presentation: 熊本大学
  • Year and Date: 2010-03-21
• [Presentation] The redox and proteolysis-coupled transcription cycles regulate the salicylic acid signaling (2010)
  • Organizer: 植物生理学会
  • Place of Presentation: 熊本
  • Year and Date: 2010-03-18
• [Presentation] 全身獲得抵抗性反応におけるレドックス制御機構 (2009)
  • Organizer: 植物病理学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-18
• [Remarks] ホームページ等
  • URL: http://www.ag.kagawa-u.ac.jp/gene/