| Project/Area Number |
21880043
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
HARADA Kazuki Nippon Veterinary and Life Science University, 獣医学部, 助教 (80549543)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWADA Takuo 日本獣医生命科学大学, 名誉教授 (30226071)
TAKAHASHI Toshio 日本獣医生命科学大学, 獣医学部, 教授 (90586273)
KATAOKA Yasushi 日本獣医生命科学大学, 獣医学部, 准教授 (60277663)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,612,000 (Direct Cost: ¥1,240,000、Indirect Cost: ¥372,000)
Fiscal Year 2010: ¥611,000 (Direct Cost: ¥470,000、Indirect Cost: ¥141,000)
Fiscal Year 2009: ¥1,001,000 (Direct Cost: ¥770,000、Indirect Cost: ¥231,000)
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| Keywords | 大腸菌 / 薬剤耐性 / 犬 / ヒト / 病原因子 / クローン / 疫学 / 遺伝子 / ESBL / 抗生物質 / 細菌 |
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| Research Abstract |
In this study, I investigated prevalence of antimicrobial resistance and their relative factors in Escherichia coli isolates from dogs and humans. Pup-origin isolates spread clonally in each kennel, resulting in different prevalence of resistance between kennels. In addition, resistance prevalence was associated with virulence factors and phylogenetic groups in dogs with urogenital infections. Furthermore, virulence factors, but not antimicrobial resistance, was more prevalent in canine isolates than in owner isolates, and genetic analysis revealed clone sharing between dogs and their owners.
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