| Project/Area Number |
21880044
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
MORI Akihiro Nippon Veterinary and Life Science University, 獣医学部, 助教 (60549559)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Keywords | 糖尿病 / 犬 / インスリン / インスリンデテミル / 人工膵臓 / インスリン抵抗性 |
|---|
| Research Abstract |
Time-action profiles of insulin detemir was evaluated in healthy and diabetic dogs. Insulin detemir could achieve intensive glycemic control in diabetic dogs. Then, we have evaluated the insulin signaling gene expression of insulin sensitive tissue in diabetic dogs with intensive glycemic control. Intensive glycemic control increased insulin signalin gene expressions in insulin sensitive tissue, which suggests amelioration of insulin resistance in diabetic dogs.
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