Elucidation of mechanisms of intestinal immunomodulation by probiotics on newly established bovine intestinal epithelial cell line.
| Project/Area Number |
21880053
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | 独立行政法人農業・食品産業技術総合研究機構・畜産草地研究所 (2010)
National Agricultural Research Organization (2009) |
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Principal Investigator |
TOHNO Masanori 独立行政法人農業・食品産業技術総合研究機構・畜産草地研究所, 機能性飼料研究チーム, 研究員 (50547718)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,808,000 (Direct Cost: ¥2,160,000、Indirect Cost: ¥648,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
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| Keywords | 畜産学 / 獣医学 / プロバイオティクス / 消化管 |
|---|
| Research Abstract |
A total of fifty-three lactic acid bacteria strains isolated from feeds and feces of livestock were subjected to phenotypic and genetic analysis, taking particular interests in the application as probiotic additives for feeds. According to expression analysis on newly established bovine intestinal epithelial cell line and tissues, the high expression of various TLRs, NOD1, and PGLYRPs were observed. Bovine intestinal epithelial cells preferentially expressed pattern-recognition receptors, which recognize not bacterial intracellular components but cell-surface components, suggesting that such pattern-recognition receptors play an important role in the recognition of intestinal microorganisms such as lactic acid bacteria.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 4.2011
Author(s)
Ueda W, M.Tohno, T.Shimazu, H.Fujie, H.Aso, Y.Kawai, M.Numasaki, T.Saito, H.Kitazawa
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Journal Title
Veterinary Immunology and Immunopathology
Related Report
Peer Reviewed
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[Presentation] Effect of immunobiotics on the immune performance and productivity of pigs2010
Author(s)
Y.Suda, Y.Takahashi, M.Tohno, J.Villena, S.Hosoya, H.Fujie, T.Shimosato, J.Kobashi, M.Ishida, H.Aso, Y.Kawai, T.Saito, S.Makino, S.Ikegami, H.Kitazawa
Organizer
International Scientific conference on Probiotics and Prebiotics-IPC2010
Place of Presentation
Kosice, Slovakia
Year and Date
2010-07-15
Related Report
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[Presentation] Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells2010
Author(s)
H.Kitazawa, T.Shimazu, M.Tohno, J.Villena, S.Hosoya, H.Fujie, Y.Suda, T.Shimosato, H.Aso, S.Makino, S.Ikegami, Y.Kawai, T.Saito
Organizer
International Scientific Conference on Probiotics and Prebiotics-IPC2010
Place of Presentation
Kosice, Slovakia
Year and Date
2010-07-15
Related Report
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