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Elucidation of mechanisms of intestinal immunomodulation by probiotics on newly established bovine intestinal epithelial cell line.

Research Project

Project/Area Number 21880053
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Zootechnical science/Grassland science
Research Institution独立行政法人農業・食品産業技術総合研究機構・畜産草地研究所 (2010)
National Agricultural Research Organization (2009)

Principal Investigator

TOHNO Masanori  独立行政法人農業・食品産業技術総合研究機構・畜産草地研究所, 機能性飼料研究チーム, 研究員 (50547718)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,808,000 (Direct Cost: ¥2,160,000、Indirect Cost: ¥648,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
Keywords畜産学 / 獣医学 / プロバイオティクス / 消化管
Research Abstract

A total of fifty-three lactic acid bacteria strains isolated from feeds and feces of livestock were subjected to phenotypic and genetic analysis, taking particular interests in the application as probiotic additives for feeds. According to expression analysis on newly established bovine intestinal epithelial cell line and tissues, the high expression of various TLRs, NOD1, and PGLYRPs were observed. Bovine intestinal epithelial cells preferentially expressed pattern-recognition receptors, which recognize not bacterial intracellular components but cell-surface components, suggesting that such pattern-recognition receptors play an important role in the recognition of intestinal microorganisms such as lactic acid bacteria.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Products Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Genotypic and phenotypic characterization of lactic acid bacteria isolated from Italian ryegrass silage.2011

    • Author(s)
      M.Tohno, H.Kobayashi, M.Nomura, M.Kitahara, M.Ohkuma, R.Uegaki, Y.Cai
    • Journal Title

      Animal Science Journal

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 4.2011

    • Author(s)
      Ueda W, M.Tohno, T.Shimazu, H.Fujie, H.Aso, Y.Kawai, M.Numasaki, T.Saito, H.Kitazawa
    • Journal Title

      Veterinary Immunology and Immunopathology

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotypic and phenotypic characterization of lactic acid bacteria isolated from Italian ryegrass silage2011

    • Author(s)
      M.Tohno, H.Kobayashi, M.Nomura, M.Kitahara, M.Ohkuma, R.Uegaki, Y.Cai
    • Journal Title

      Animal Science Journal

      Volume: (掲載決定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of lactic acid bacteria isolated from mixed pasture of timothy and orohardgrass, and its badly preserved silage2011

    • Author(s)
      M.Tohno, H.Kobayashi, M.Nomura, R.Uegaki, Y.Cai
    • Journal Title

      Animal Science Journal

      Volume: (掲載決定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of innate immunity by lactic acid bacteria : impact on host response to infections2010

    • Author(s)
      Susana Alvarez, Masanori Tohno, 他
    • Journal Title

      Current Research in Immunology 3

      Pages: 87-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of lactic acid bacteria isolated from mixed pasture of timothy and orchardgrass, and its badly preserved silage.

    • Author(s)
      M.Tohno, H.Kobayashi, M.Nomura, R.Uegaki, Y.Cai
    • Journal Title

      Animal Science Journal, Accepted

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] NOD受容体を介するペプチドグリカン断片の免疫刺激微細構造2010

    • Author(s)
      遠野雅徳、島津朋之、下里剛士、麻生久、齋藤忠夫、北澤春樹
    • Organizer
      平成22年度日本酪農科学シンポジウム
    • Place of Presentation
      長野
    • Year and Date
      2010-08-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Immunobiotic Evaluation System for Functional Foods and Feeds2010

    • Author(s)
      H.Kitazawa, M.Tohno, T.Shimosato, Y.Suda, H.Aso
    • Organizer
      14th AAAP Animal Science Congress
    • Place of Presentation
      Pingtung, Taiwan
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Streptococcus thermophilus由来CpG DNAが誘導するIL-33の機能性解析2010

    • Author(s)
      下里剛士、畑野木の実、遠野雅徳、大谷元、北澤春樹
    • Organizer
      H22年度日本酪農科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of immunobiotics on the immune performance and productivity of pigs2010

    • Author(s)
      Y.Suda, Y.Takahashi, M.Tohno, J.Villena, S.Hosoya, H.Fujie, T.Shimosato, J.Kobashi, M.Ishida, H.Aso, Y.Kawai, T.Saito, S.Makino, S.Ikegami, H.Kitazawa
    • Organizer
      International Scientific conference on Probiotics and Prebiotics-IPC2010
    • Place of Presentation
      Kosice, Slovakia
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells2010

    • Author(s)
      H.Kitazawa, T.Shimazu, M.Tohno, J.Villena, S.Hosoya, H.Fujie, Y.Suda, T.Shimosato, H.Aso, S.Makino, S.Ikegami, Y.Kawai, T.Saito
    • Organizer
      International Scientific Conference on Probiotics and Prebiotics-IPC2010
    • Place of Presentation
      Kosice, Slovakia
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus2010

    • Author(s)
      T.Shimosato, M.Fujimoto, M.Tohno, T.Sato, H.Ohtani, H.Kitazawa
    • Organizer
      ADSA-PSA-AMPA-CSAS-ASAS Joint annual meeting
    • Place of Presentation
      Denvor, Colorado
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳酸菌由来CpG DNAによるToll様受容体9を介するIL-33の発現増強2010

    • Author(s)
      下里剛士、藤本恵、遠野雅徳、大谷元、北澤春樹
    • Organizer
      日本食品免疫学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] チモシー・オーチャードグラス混播牧草由来乳酸菌の性状とその多様性2010

    • Author(s)
      遠野雅徳、小林寿美、〓会利、曹陽、上垣隆一、蔡義民
    • Organizer
      日本草地学会
    • Place of Presentation
      三重
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] チモシー・オーチャードグラス混播牧草由来乳酸菌の性状とその多様性2010

    • Author(s)
      遠野雅徳、小林寿美、〓会利、曹陽、上垣隆一、蔡義民
    • Organizer
      日本草地学会
    • Place of Presentation
      三重大学
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腸管免疫系におけるプロバイオティクスによるNODの発現増強と可溶性ペプチドグリカンフラグメント微細構造の免疫活性相関2009

    • Author(s)
      遠野雅徳、島津朋之、下里剛士、麻生久、齋藤忠夫、北澤春樹
    • Organizer
      日本食品免疫学会2009年度大会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-26
    • Related Report
      2010 Final Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス(第二章乳酸菌・ビフィズス菌の構造と生理、細胞壁の多糖成分(a)ペプチドグリカン,(b)細菌細胞壁とテイコ酸、テイクロン酸)2011

    • Author(s)
      遠野雅徳
    • Total Pages
      10
    • Publisher
      京都大学学術出版
    • Related Report
      2010 Final Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス(第四章乳酸菌・ビフィズス菌の産生する有用物質、菌体外多糖:EPSとペプチドグリカン)2011

    • Author(s)
      遠野雅徳、北澤春樹
    • Total Pages
      8
    • Publisher
      京都大学学術出版
    • Related Report
      2010 Final Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス、第二章乳酸菌・ビフィズス菌の構造と生理、細胞壁の多糖成分(a)ペプチドグリカン,(b)細菌細胞壁とテイコ酸、テイクロン酸2011

    • Author(s)
      遠野雅徳
    • Total Pages
      10
    • Publisher
      京都大学学術出版会
    • Related Report
      2010 Annual Research Report
  • [Book] 乳酸菌とビフィズス菌のサイエンス、第四章乳酸菌・ビフィズス菌の産生する有用物質、菌体外多糖:EPSとペプチドグリカン2011

    • Author(s)
      遠野雅徳、北澤春樹
    • Total Pages
      8
    • Publisher
      京都大学学術出版会
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://nilgs.naro.affrc.go.jp/

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] グアイアコール認識性を指標に選抜した微生物と微生物増殖促進活性を有するグアイアコール含有組成物2012

    • Inventor(s)
      遠野 雅徳
    • Industrial Property Rights Holder
      独立行政法人農業・食品産業技術総合研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-084340
    • Filing Date
      2012-04-02
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 非公表2011

    • Inventor(s)
      遠野雅徳
    • Industrial Property Rights Holder
      独立行政法人農業・食品産業技術総合研究機構
    • Industrial Property Number
      2011-079264
    • Filing Date
      2011-03-31
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-09-09  

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