Research Project
Grant-in-Aid for Research Activity Start-up
X11/X11L doubly-deficient mice suffered from spontaneous epileptic seizures and hyperpolarization-activated cyclic nucleotide gated (HCN) channels function were reduced in X11/X11L doubly-deficient mice brain. The number of amyloid deposits in X11L-KO/APP23 Tg mice brains were significantly increased. The functional domains of X11 proteins to suppress the metabolism of amyloid precursore protein (APP) were carboxy-terminal PDZ domains.
All 2011 2010 2009 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (23 results) Book (2 results) Remarks (1 results)
Mol.Neurodegener. 5
Pages: 35-35
120005158908
J.Neurochem. 111
Pages: 1213-24
Mol. Neurodegener.
Volume: 5:35 Pages: 1-11
Journal of Neurochemistry Vol.111
Pages: 1213-1224
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