Analysis of X11 proteins functions in vivo
Project/Area Number |
21890002
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
|
Research Institution | Hokkaido University |
Principal Investigator |
SAITO Yuhki Hokkaido University, 大学院・薬学研究院, 助教 (70548180)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
|
Keywords | アルツハイマー病 / てんかん / X11 / Aβ / X11L |
Research Abstract |
X11/X11L doubly-deficient mice suffered from spontaneous epileptic seizures and hyperpolarization-activated cyclic nucleotide gated (HCN) channels function were reduced in X11/X11L doubly-deficient mice brain. The number of amyloid deposits in X11L-KO/APP23 Tg mice brains were significantly increased. The functional domains of X11 proteins to suppress the metabolism of amyloid precursore protein (APP) were carboxy-terminal PDZ domains.
|
Report
(3 results)
Research Products
(30 results)
-
[Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.2010
Author(s)
Maho Kondo, Maki Shiono, Genzo Ito, Norio Takei, Takahide Matsushima, Masahiro Maeda, Hidenori Taru, Saori Hata, Tohru Yamamoto, Yuhki Saito, Toshiharu Suzuki
-
Journal Title
Mol.Neurodegener. 5
Pages: 35-35
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-