Glucose- and temperature- dependent regulation of spontaneous firing in SNr GABAergic neurons

Research Project

Project/Area Number	21890007
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	General physiology
Research Institution	Hirosaki University
Principal Investigator	NAGATOMO Katsuhiro Hirosaki University, 大学院・医学研究科, 奨励研究員 (30542568)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000) Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000) Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords	自発発火 / グルコース / 温度 / 脳・神経 / 生理 / 代謝 / 生理学
Research Abstract	It has not been identified that regulatory mechanisms of persistent high frequency spontaneous firing in SNr GABAergic neuron. Glucose- and temperature- dependent regulation of spontaneous firing in acutely dissociated SNr GABAergic neuron was investigated. Glucose- and temperature- dependent regulation of spontaneous firing in acutely dissociated GABAergic neuron was distinct from the results of the extracellular recording in acute brain slices (Yuan, H. et al, Neurosci Lett 2004). These results suggest that the spontaneous firing in SNr GABAergic neuron could be regulated by the environment around a neuron in brain.

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